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Related Concept Videos

Necrosis01:16

Necrosis

Necrosis is considered as an “accidental” or unexpected form of cell death that ends in cell lysis. The first noticeable mention of “necrosis” was in 1859 when Rudolf Virchow used this term to describe advanced tissue breakdown in his compilation titled “Cell Pathology”.
Morphological Manifestations of Necrosis
Necrotic cells show different types of morphological appearance depending on the type of tissue and infection. In coagulative necrosis, cells become anucleated and die, but their...
Cellular Injury IV: Necrosis01:16

Cellular Injury IV: Necrosis

Necrosis is a form of irreversible cell death caused by severe injury such as ischemia, toxins, or trauma. Unlike programmed cell death, it is an uncontrolled, pathological process that typically provokes inflammation in surrounding tissues.Pathophysiologic ChangesNecrosis begins when cells sustain critical damage, leading to swelling of organelles, particularly mitochondria, and rapid ATP depletion. As energy levels decline, membrane ion pumps fail, leading to calcium influx and eventually,...
Inhalation Anthrax01:25

Inhalation Anthrax

Anthrax is a zoonotic disease caused by Bacillus anthracis, a Gram-positive, spore-forming bacterium. It primarily affects herbivorous animals but can be transmitted to humans through skin contact, ingestion, or inhalation of spores.Cutaneous anthrax, the most common form, typically results from direct contact with bacterial spores through skin abrasions and is generally less severe. Gastrointestinal anthrax results from eating undercooked or contaminated meat. It affects the mouth, throat, or...
Rocky Mountain Spotted Fever01:26

Rocky Mountain Spotted Fever

Rocky Mountain Spotted Fever (RMSF) is a severe tick-borne illness caused by Rickettsia rickettsii, a Gram-negative, coccobacillary bacterium. This pathogen is an obligate intracellular parasite, requiring a host cell for replication. Transmission occurs through the bite of an infected tick. In the United States, the most important vectors are Dermacentor variabilis (American dog tick) and Dermacentor andersoni (Rocky Mountain wood tick), though other tick species may also serve as vectors.
Burn Injuries01:22

Burn Injuries

Burn injuries occur when the skin and underlying tissues are damaged due to exposure to heat, electricity, chemicals, radiation, or friction. They can vary in severity, from minor superficial burns to severe deep burns that can be life-threatening.
The damage results in the death of skin cells, which can lead to a massive loss of fluid. Dehydration, electrolyte imbalance, and renal and circulatory failure follow, which can be fatal. Burn patients are treated with intravenous fluids to offset...

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Related Experiment Video

Updated: Jun 23, 2026

A Contemporary Warming/Restraining Device for Efficient Tail Vein Injections in a Murine Fungal Sepsis Model
06:02

A Contemporary Warming/Restraining Device for Efficient Tail Vein Injections in a Murine Fungal Sepsis Model

Published on: November 6, 2020

Mortality in necrotizing fasciitis.

Akram Rajput1, Waseem, Abdul Samad

  • 1Department of Surgery, Isra University, Hyderabad. akramrajput2006@yahoo.com

Journal of Ayub Medical College, Abbottabad : JAMC
|April 24, 2009
PubMed
Summary

Necrotizing Fasciitis has a high mortality rate of 26.6%. Early diagnosis and treatment, especially for conditions like diabetes mellitus, are crucial for improving patient outcomes and survival rates.

Related Experiment Videos

Last Updated: Jun 23, 2026

A Contemporary Warming/Restraining Device for Efficient Tail Vein Injections in a Murine Fungal Sepsis Model
06:02

A Contemporary Warming/Restraining Device for Efficient Tail Vein Injections in a Murine Fungal Sepsis Model

Published on: November 6, 2020

Area of Science:

  • Infectious Diseases
  • Surgical Pathology
  • Critical Care Medicine

Background:

  • Necrotizing Fasciitis is a severe, rapidly progressing soft tissue infection.
  • Prompt diagnosis and aggressive management are critical for patient survival.

Purpose of the Study:

  • To determine the mortality rate of Necrotizing Fasciitis.
  • Identify risk factors and common microorganisms associated with mortality.

Main Methods:

  • Prospective study of patients aged over 12 years admitted with Necrotizing Fasciitis.
  • Inclusion of emergency exploration, surgical debridement, and post-operative care.
  • Follow-up for up to two years.

Main Results:

  • 25 males and 5 females included; common symptoms: redness, swelling, fever, skin necrosis.
  • Diabetes Mellitus was the most common predisposing factor; perineum was the most common site.
  • Bacteroides and E. coli were prevalent; Bacteroides was common in non-survivors.

Conclusions:

  • Necrotizing Fasciitis presents a significant mortality risk (26.6%).
  • Factors increasing mortality include delayed diagnosis, old age, diabetes, truncal/anorectal involvement.
  • Hyperbaric oxygen and unprocessed honey may reduce mortality.