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Updated: Jun 23, 2026

Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes

Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes

Published on: September 26, 2013

Barrier immunity and IL-17.

Benjamin R Marks¹, Joe Craft

¹Department of Immunobiology, Yale School of Medicine, New Haven, CT 06520, USA.

Seminars in Immunology

|April 24, 2009

Summary

This summary is machine-generated.

Helper T 17 (T(H)17) cells are crucial for immunity at body barriers, aiding microorganism clearance but risking autoimmunity. These cells share developmental pathways with regulatory T (T(R)) cells, vital for immune regulation and barrier protection.

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Area of Science:

Immunology
Cellular Biology
Microbiology

Background:

CD4+ T helper 17 (T(H)17) cells are key players in barrier immunity, essential for combating pathogens.
Dysregulated T(H)17 cell activity can lead to autoimmune conditions at barrier sites.
CD4+ regulatory T (T(R)) cells also play a critical role in maintaining immune homeostasis and protecting barriers.

Purpose of the Study:

To discuss the development and function of T(H)17 cells.
To explore the relationship between T(H)17 cells and T(R) cells.
To highlight the shared pathways and distinct roles of these T cell populations in immunity.

Main Methods:

Review of recent scientific literature.
Analysis of immunological pathways.
Comparative study of T cell subsets.

Main Results:

T(H)17 cells are critical for host defense against microorganisms.
T(H)17 cells have the potential to induce autoimmunity.
T(H)17 cells and T(R) cells share common developmental and functional pathways.

Conclusions:

Understanding the interplay between T(H)17 and T(R) cells is vital for immune regulation.
Targeting these pathways may offer therapeutic strategies for autoimmune diseases and infections.