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Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features

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Related Experiment Video

Updated: Jun 23, 2026

Real-time Imaging of Leukotriene B4 Mediated Cell Migration and BLT1 Interactions with β-arrestin

Real-time Imaging of Leukotriene B₄ Mediated Cell Migration and BLT1 Interactions with β-arrestin

Published on: December 23, 2010

CTLA4 gene polymorphisms are associated with chronic bronchitis.

G Zhu¹, A Agusti, A Gulsvik

¹Glaxo SmithKline R&D, Research Triangle Park, NC 27709, USA.

The European Respiratory Journal

|April 24, 2009

Summary

Genetic variations in the CTLA4 gene are linked to chronic bronchitis in patients with chronic obstructive pulmonary disease (COPD). This finding suggests CTLA4 plays a role in COPD development and progression.

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A Method to Study the C924T Polymorphism of the Thromboxane A2 Receptor Gene

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Published on: April 1, 2019

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A Method to Study the C924T Polymorphism of the Thromboxane A2 Receptor Gene

A Method to Study the C924T Polymorphism of the Thromboxane A2 Receptor Gene

Published on: April 1, 2019

Area of Science:

Genetics
Immunology
Pulmonology

Background:

Chronic obstructive pulmonary disease (COPD) involves progressive respiratory symptoms.
T-lymphocytes and CTLA4 gene are implicated in COPD pathogenesis.
CTLA4 modulates T-cell activation, making it a candidate gene for COPD.

Purpose of the Study:

To assess the genetic association between CTLA4 single nucleotide polymorphisms (SNPs) and chronic bronchitis in COPD patients.
To identify specific CTLA4 SNPs associated with chronic bronchitis.
To validate these associations in an independent cohort.

Main Methods:

Genetic association study using nine CTLA4 SNPs in 1,896 individuals from the International COPD Genetics Network (ICGN).
Replication analysis in 342 COPD subjects with chronic bronchitis and 511 without, from Bergen, Norway.
Family-based association tests (ICGN) and logistic regression (Bergen cohort) were employed.

Main Results:

Six CTLA4 SNPs showed significant association with chronic bronchitis in the ICGN cohort.
Three of these SNPs were replicated in the Bergen cohort with consistent directionality.
One replicated SNP (rs231775) results in a Thr to Ala amino acid substitution.

Conclusions:

CTLA4 is likely a genetic determinant of chronic bronchitis in COPD cases.
The findings support the role of CTLA4 in the pathogenesis of chronic bronchitis.
Specific CTLA4 SNPs may serve as biomarkers for chronic bronchitis risk in COPD.