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Published on: January 28, 2020

Correlation of serum S100B concentration with hospital stay in patients undergoing CABG

Ljuba Krnjak1, Primoz Trunk, Borut Gersak

  • 1Clinical Institute of Clinical Chemistry and Clinical Biochemistry, University Medical Center, Ljubljana, Slovenia. ljuba.krnjak@kclj.si

Acta Clinica Croatica
|April 25, 2009
PubMed

Insights

Serum S100B protein levels on postoperative days 1 and 5 correlate with hospital stay length in coronary artery bypass grafting patients. This suggests S100B may predict outcomes even without evident cerebral injury.

Area of Science:

  • Biochemistry
  • Neurology
  • Cardiovascular Surgery

Background:

  • S100B protein is a potential serum marker for cerebral injury following cardiac surgery.
  • Assessing predictive markers for patient outcomes after coronary artery bypass grafting (CABG) is crucial.

Purpose of the Study:

  • To investigate the correlation between serum S100B protein concentration and hospital stay duration in CABG patients.
  • To determine if elevated S100B levels post-surgery predict longer hospitalizations, even in the absence of clinical neurological deficits.

Main Methods:

  • Serum S100B levels were measured preoperatively, immediately post-operation, and on postoperative days 1 and 5 in 32 CABG patients.
  • Multivariate linear regression analysis was employed to assess correlations, controlling for operation type and patient characteristics.

Main Results:

  • Median hospital stay was 7 days (range: 5-34 days).
  • Serum S100B concentrations were significantly elevated post-operation and on day 1 and day 5 compared to preoperative levels.
  • S100B levels on postoperative day 1 (p=0.0296) and day 5 (p=0.0021) independently correlated with length of hospital stay.

Conclusions:

  • Postoperative serum S100B concentration on days 1 and 5 may serve as a prognostic indicator for hospital stay duration in CABG patients.
  • These findings suggest S100B could predict outcomes even in patients without overt clinical signs of cerebral injury.
  • Further validation in larger patient cohorts is recommended to confirm these preliminary results.

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