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Updated: Jun 23, 2026

Combined Genetic and Chemical Capsid Modifications of Adenovirus-Based Gene Transfer Vectors for Shielding and Targeting
Published on: October 26, 2018
Dendrimers as synthetic gene vectors: cell membrane attachment
N K Voulgarakis1, K Ø Rasmussen, P M Welch
1Theoretical Division and Center for Nonlinear Studies, Los Alamos National Laboratory, Los Alamos, New Mexico 87545, USA. nvoul@berkeley.edu
Abstract:
We present molecular-level simulations of dendrimer/DNA complexes in the presence of a model cell membrane. We determine the required conditions for the complex to arrive intact at the membrane, and the lifetime of the complex as it resides attached to the membrane. Our simulations directly pertain to critical issues arising in emerging gene delivery therapeutic applications, where a molecular carrier is required to deliver DNA segments to the interior of living cells.

