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Isolation of mutants blocked in calicheamicin biosynthesis
1Department of Microbial Genetics, Lederle Laboratories, Pearl River, New York 10965.
Journal of Bacteriology
|December 1, 1991
Abstract:
Blocked mutants of Micromonospora echinospora defective in the production of the potent antitumor agent calicheamicin are described. Analysis of intermediates produced by blocked mutants indicates a branched biosynthetic pathway. Mutants that produced some, but not all, calicheamicin forms are also described.