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Related Experiment Videos

Obsessive compulsive disorder, depression, and fluoxetine.

E Hollander1, L Mullen, C M DeCaria

  • 1Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, NY 10032.

The Journal of Clinical Psychiatry
|October 1, 1991
PubMed
Summary

Fluoxetine may cause depressive symptoms in some patients with obsessive compulsive disorder (OCD). Combining fluoxetine with tricyclic antidepressants or switching to clomipramine may help manage these symptoms.

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Area of Science:

  • Psychiatry
  • Pharmacology
  • Clinical Psychology

Background:

  • Selective serotonin reuptuptake blockers (SSRIs) like fluoxetine are used for obsessive compulsive disorder (OCD).
  • Depression often complicates OCD and can hinder treatment effectiveness.

Observation:

  • This study examined pilot data from 10 outpatients with OCD during an open-label fluoxetine trial.
  • The focus was on patients experiencing depressive reactions or inadequate antidepressant response.

Findings:

  • High-dose fluoxetine was linked to depressive symptoms in 6 out of 10 patients.
  • Adding a tricyclic antidepressant to fluoxetine improved depression in 8 patients.
  • Switching to clomipramine resolved both OCD and depressive symptoms in 5 patients.

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Implications:

  • Clinicians should be aware of potential depressive reactions to fluoxetine in OCD patients.
  • Further controlled trials are needed to confirm these observations.
  • Combined fluoxetine-tricyclic treatment or switching to clomipramine may be viable strategies for managing depression in this population.