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Updated: Jun 23, 2026

Modeling the Functional Network for Spatial Navigation in the Human Brain
Published on: October 13, 2023
Integrative decomposition procedure and Kappa statistics for the distinguished single molecular network construction
Lin Wang1, Ying Sun, Minghu Jiang
1Biomedical Center, School of Electronics Engineering, Beijing University of Posts and Telecommunications, Beijing 100876, China. wanglin98@tsinghua.org.cn
Abstract:
Our method concentrates on and constructs the distinguished single gene network. An integrated method was proposed based on linear programming and a decomposition procedure with integrated analysis of the significant function cluster using Kappa statistics and fuzzy heuristic clustering. We tested this method to identify ATF2 regulatory network module using data of 45 samples from the same GEO dataset. The results demonstrate the effectiveness of such integrated way in terms of developing novel prognostic markers and therapeutic targets.
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