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Published on: July 31, 2016
Chemo-hyperthermic peritoneal perfusion (CHPP) for appendiceal pseudomyxoma peritonei.
Kanji Katayama1, Akio Yamaguchi, Makoto Murakami
1First Department of Surgery, University of Fukui, School of Medicine, 23 Shimoaizuki, Matsuoka, Eiheiji-cho, Fukui, 910-1193, Japan. kanji@u-fukui.ac.jp
International Journal of Clinical Oncology
|April 25, 2009
Summary
High-temperature chemo-hyperthermic peritoneal perfusion is an effective treatment for pseudomyxoma peritonei, even after incomplete tumor removal. This approach offers a promising alternative for patients with this rare condition.
Area of Science:
- Oncology
- Surgical Oncology
- Gastroenterology
Background:
- Pseudomyxoma peritonei originates from appendiceal tumors, characterized by mucinous substance production.
- Despite low malignancy, radical resection is challenging, leading to poor prognosis.
- Current treatments involve chemo-hyperthermia with subtotal peritonectomy in Western centers.
Purpose of the Study:
- To evaluate the efficacy of high-temperature chemo-hyperthermic peritoneal perfusion (HT-CHPP) after incomplete tumor resection for pseudomyxoma peritonei.
- To compare outcomes with existing treatments that include peritonectomy.
Main Methods:
- Six patients with mucinous tumors underwent incomplete resection followed by HT-CHPP.
- Heated perfusate with anticancer agents circulated in the peritoneal cavity, maintaining a surface temperature of approximately 43°C.
- Tumor dissemination was addressed via macroscopic gross tumor resection prior to perfusion.
Main Results:
- The intraperitoneal space was safely heated to the target temperature without severe complications.
- Pathological diagnoses included peritoneal mucinous carcinomatosis and an intermediate type.
- Survival rates were comparable to or better than those reported for treatments involving peritonectomy and mild hyperthermia.
Conclusions:
- High-temperature chemo-hyperthermic peritoneal perfusion is effective for pseudomyxoma peritonei.
- This method shows efficacy even when complete peritonectomy is not performed.
- The treatment offers a viable option for managing pseudomyxoma peritonei, potentially improving patient outcomes.
