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Immunocytochemistry and Immunohistochemistry

Immunocytochemistry and Immunohistochemistry

Immunocytochemistry (ICC) and immunohistochemistry (IHC) are techniques that use antibodies to check for specific proteins or antigens in a sample. The technique was first published by Albert Coons in 1941 to detect the presence of pneumococcal antigen in tissue sections from mice infected with Pneumococcus. Immunocytochemistry helps localization of proteins or antigens in individual cells like blood cells, stem cells, etc., while immunohistochemistry does the same for tissue samples.
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Related Experiment Video

Updated: Jun 23, 2026

Visualization, Quantification, and Mapping of Immune Cell Populations in the Tumor Microenvironment

Visualization, Quantification, and Mapping of Immune Cell Populations in the Tumor Microenvironment

Published on: March 25, 2020

Practice evolution: decentralized computer-assisted immunohistochemical image analysis

Richard C Friedberg¹, Liron Pantanowitz

¹Department of Pathology, Baystate Health, Springfield, MA 01199, USA. richard.friedberg@bhs.org

Archives of Pathology & Laboratory Medicine

|April 28, 2009

Summary

No abstract available in PubMed .

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