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Updated: Jun 23, 2026

An Adoptive Transfer Model of Rheumatoid Arthritis in Mice
Published on: June 6, 2025
RNA interference-based gene therapy for successful treatment of rheumatoid arthritis
Gabriel Courties1, Jessy Presumey, Isabelle Duroux-Richard
1Inserm, U844, Université Montpellier 1, CHU Lapeyronie, Montpellier, France.
Background:
RNA interference (RNAi) is a powerful endogenous process initiated by short double-stranded RNAs, which results in sequence-specific posttranscriptional gene silencing. The possibility of blocking the expression of any protein carries huge expectations for potential therapeutic applications in a wide range of diseases. For clinical development, however, the use of RNAi-based therapeutics has to overcome major obstacles, mainly targeted delivery and safety issues.
Objective/Methods:
In this short review, we provide an overview of specifications for RNAi-based gene therapy in rheumatoid arthritis (RA) and discuss recent progresses in the development of efficient silencing, focusing on expression of short hairpin RNAs.
Results/Conclusions:
Combining advances in RNAi methodology with gene therapy technology opens avenues for rapid applications to RA.
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