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Automated Analysis of a Nematode Population-based Chemosensory Preference Assay
Published on: July 13, 2017
Medullary serotonin neurons and central CO2 chemoreception
Andrea E Corcoran1, Matthew R Hodges, Yuanming Wu
1Department of Biology and Wildlife, University of Alaska Fairbanks, Fairbanks, AK 99775, USA. ftaec1@uaf.edu
Respiratory Physiology & Neurobiology
|April 28, 2009
Summary
Serotonin (5-HT) neurons in the brainstem may act as central respiratory chemoreceptors. Evidence suggests these neurons detect carbon dioxide levels and regulate breathing, crucial for maintaining homeostasis.
Area of Science:
- Neuroscience
- Respiratory Physiology
- Homeostasis
Background:
- Serotonergic (5-HT) neurons are proposed as central respiratory chemoreceptors.
- These neurons are chemosensitive and located near medullary arteries, consistent with chemoreceptor function.
Purpose of the Study:
- To review evidence supporting the role of 5-HT neurons as central chemoreceptors.
- To address counterarguments and explore interactions with other chemosensitive sites.
Main Methods:
- Review of existing literature, including in vivo and in vitro studies.
- Analysis of data from transgenic and knockout mouse models.
- Exploration of neuroanatomical relationships.
Main Results:
- 5-HT neurons in the medullary raphé are stimulated by hypercapnia.
- Disruption of these neurons impairs ventilatory responses to hypercapnia.
- Transgenic and knockout mouse data further implicate 5-HT in chemosensitivity.
Conclusions:
- Current evidence supports the hypothesis that 5-HT neurons function as central chemoreceptors.
- Further research is needed to fully elucidate their role and interactions with other respiratory control centers.
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