Related Experiment Video
Updated: Jun 23, 2026

09:33
Three-dimensional Rendering and Analysis of Immunolabeled, Clarified Human Placental Villous Vascular Networks
Published on: March 29, 2018
Placental polyp with prominent neovascularization
Akihiro Takeda1, Kazuyuki Koyama, Sanae Imoto
1Department of Obstetrics and Gynecology, Gifu Prefectural Tajimi Hospital, 5-161 Maebata-cho, Tajimi, Gifu 507-8522, Japan. gyendoscopy@gmail.com
Fertility and Sterility
|April 28, 2009
Summary
Placental polyps, a serious postpartum complication, can be managed using multimodal imaging to assess neovascularization. This approach aids fertility preservation in affected women.
Area of Science:
- Reproductive Medicine
- Obstetrics & Gynecology
- Medical Imaging
Background:
- Placental polyps are a significant, potentially life-threatening complication following abortion or parturition.
- Effective management strategies are crucial, particularly for women desiring future fertility.
Observation:
- Neovascularization is a key pathological feature in placental polyp development.
- Multimodal imaging offers a non-invasive method to evaluate vascularity within placental polyps.
Findings:
- The study explores the utility of multimodal imaging in assessing neovascularization in placental polyps.
- This imaging approach provides detailed insights into the vascular architecture of the polyp.
Implications:
- Accurate assessment of neovascularization may guide conservative management strategies.
- Preserving fertility is a critical consideration in managing placental polyps, and imaging can inform treatment decisions.
Related Concept Videos
Development of Blood Vessels
The development of the vascular system in a fetus is a complex and intricate process that begins as early as 15 to 16 days post-conception. This process starts outside the embryo, specifically in the mesoderm of the yolk sac, chorion, and connecting stalk. Approximately two days later, the formation of blood vessels occurs within the embryo itself.
The initial formation of this system is facilitated by the small amount of yolk present in the ovum and yolk sac. Blood vessels originate from...
The initial formation of this system is facilitated by the small amount of yolk present in the ovum and yolk sac. Blood vessels originate from...
Fetal Circulation
Fetal circulation is a unique system that facilitates the exchange of gases, nutrients, and waste products between the developing fetus and the mother. This intricate process takes place through a special organ called the placenta.
Two umbilical arteries transport blood from the fetus to the placenta. At the placenta, the blood absorbs oxygen and nutrients while simultaneously eliminating waste products. This oxygen-enriched and nutrient-rich blood then returns to the fetus through one...
Two umbilical arteries transport blood from the fetus to the placenta. At the placenta, the blood absorbs oxygen and nutrients while simultaneously eliminating waste products. This oxygen-enriched and nutrient-rich blood then returns to the fetus through one...
Regulation of Angiogenesis and Blood Supply
Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits. Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl hydroxylase and factor...
