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Isohumulones, the bitter component of beer, improve hyperglycemia and decrease body fat in Japanese subjects with
Kuniaki Obara1, Mai Mizutani, Yoshitaka Hitomi
1Research and Development Laboratory, Kirin Beverage Company Ltd, Yokohama, Japan. k-obara@kirin.co.jp
Clinical Nutrition (Edinburgh, Scotland)
|April 28, 2009
Summary
Isohumulones, found in beer, may help manage prediabetes. This study showed isohumulones reduced blood glucose, HbA1c, BMI, and body fat in prediabetic subjects.
Area of Science:
- Metabolic Health
- Nutraceutical Research
Background:
- Isohumulones, beer's bitter compounds, activate PPARalpha and PPARgamma.
- Previous studies indicated potential glucose and lipid-lowering effects in diabetic mice.
Purpose of the Study:
- To investigate the efficacy and safety of isohumulones in individuals with prediabetes.
- To determine optimal dosages for potential therapeutic benefits.
Main Methods:
- A 12-week, double-blind, randomized, placebo-controlled study.
- Ninety-four prediabetic subjects received placebo or 16 mg, 32 mg, or 48 mg of isohumulones daily.
- Dose-finding approach to assess safety and efficacy.
Main Results:
- Significant reductions in fasting blood glucose observed at 32 mg and 48 mg doses.
- HbA1c levels decreased significantly across multiple dosage groups.
- Body Mass Index (BMI) and total body fat area decreased significantly in the 48 mg group compared to placebo.
Conclusions:
- Isohumulone supplementation demonstrates beneficial effects for prediabetes management.
- Potential therapeutic applications for isohumulones in addressing metabolic dysfunction and obesity.
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