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A Simple Mechanical Procedure to Create Limbal Stem Cell Deficiency in Mouse
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Published on: November 17, 2016

Schnyder corneal dystrophy.

Jayne S Weiss1

  • 1Kresge Eye Institute, Wayne State University School of Medicine, Detroit, Michigan 48302, USA. jweiss@med.wayne.edu

Current Opinion in Ophthalmology
|April 29, 2009
PubMed
Summary
This summary is machine-generated.

Schnyder corneal dystrophy (SCD) is often misdiagnosed. This review clarifies clinical findings, noting corneal crystals are present in only 54% of patients, and visual loss necessitates surgery in most over 50.

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Area of Science:

  • Ophthalmology
  • Genetics
  • Corneal Diseases

Background:

  • Schnyder corneal dystrophy (SCD) is a rare genetic eye disease.
  • Previous literature contains misconceptions regarding SCD's clinical presentation and diagnosis.
  • Accurate understanding of clinical findings is crucial for timely diagnosis.

Purpose of the Study:

  • To correct misconceptions about Schnyder corneal dystrophy (SCD) in published literature.
  • To clarify the clinical findings and facilitate diagnosis of SCD.
  • To provide updated information on the long-term visual morbidity associated with SCD.

Main Methods:

  • Retrospective case series analysis of 115 individuals from 34 SCD families.
  • Review of clinical findings and long-term visual outcomes in a large cohort.
  • Analysis of data on corneal clouding progression, presence of corneal crystals, and outcomes of penetrating keratoplasty.

Main Results:

  • Progressive corneal clouding in SCD follows a predictable pattern based on age.
  • Corneal crystals, often cited for diagnosis, were present in only 54% of affected patients.
  • Penetrating keratoplasty was performed in 54% of patients over 50 and 77% over 70, with significant visual improvement in many.

Conclusions:

  • Published literature on SCD requires revision to incorporate new findings.
  • Corneal crystals aid diagnosis but are not universally present (54%).
  • Photopic vision loss and glare are significant, often necessitating penetrating keratoplasty in patients over 50.