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Related Experiment Video

Updated: Jun 23, 2026

A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma
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Published on: September 30, 2021

Experimental models of hepatocellular carcinoma: developments and evolution.

Long Wu1, Zhao-You Tang, Yan Li

  • 1Department of Oncology, Zhongnan Hospital of Wuhan University and Hubei Key Laboratory of Tumour Biological Behaviors, No 169 Donghu Road, Wuchang District, 430071 Wuhan, China.

Journal of Cancer Research and Clinical Oncology
|April 29, 2009
PubMed
Summary

Hepatocellular carcinoma (HCC) research utilizes diverse experimental models to understand cancer development and test therapies. This review details advancements in HCC models, aiding future investigations.

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Last Updated: Jun 23, 2026

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Area of Science:

  • Oncology
  • Hepatology
  • Cancer Research

Background:

  • Hepatocellular carcinoma (HCC) is a prevalent global malignancy.
  • The biological mechanisms driving hepatocarcinogenesis and HCC progression remain incompletely understood.
  • Experimental models are crucial for investigating HCC risk factors, treatments, and biological features.

Purpose of the Study:

  • To review the evolution and current state of experimental models for hepatocellular carcinoma research.
  • To summarize the advantages and disadvantages of various HCC model systems.
  • To highlight the utility of these models in understanding HCC biology and testing therapeutic strategies.

Main Methods:

  • Review of spontaneous, induced, viral, transplantable, and genetically engineered models of HCC.
  • Analysis of model applications in studying basic biological mechanisms (growth, differentiation, oncogene function).
  • Evaluation of models for testing novel diagnostic and therapeutic approaches in HCC.

Main Results:

  • Emergence of diverse experimental HCC models with continuous technological advancements.
  • Each model type offers unique advantages and disadvantages for specific research questions.
  • Models are instrumental in advancing the understanding of HCC pathogenesis and treatment efficacy.

Conclusions:

  • Experimental models are indispensable tools for advancing hepatocellular carcinoma research.
  • Continued development and refinement of HCC models are essential for future discoveries.
  • A comprehensive understanding of available models facilitates effective research design and therapeutic development.