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Green tea: nature's defense against malignancies
Masood Sadiq Butt1, Muhammad Tauseef Sultan
1National Institute of Food Science and Technology, University of Agriculture, Faisalabad. drmsbutt@yahoo.com
Critical Reviews in Food Science and Nutrition
|April 29, 2009
Summary
Green tea
Area of Science:
- Phytochemicals and Nutritional Therapy
- Cancer Prevention and Immunology
Background:
- Traditional use of phytochemicals for health support.
- Green tea's constituents, particularly polyphenols like epigallocatechin-3-gallate (EGCG), are key in diet-based cancer prevention strategies.
- Polyphenols mitigate oxidative stress and possess anti-carcinogenic and anti-mutagenic properties.
Purpose of the Study:
- To review the chemistry and antioxidant potential of green tea.
- To highlight green tea's immunopotentiating properties.
- To elucidate green tea's mechanisms of action against various cancer cell lines.
Main Methods:
- Literature review focusing on green tea's chemical composition.
- Analysis of studies on green tea's antioxidant and immunomodulatory effects.
- Examination of research on EGCG's role in cancer chemoprevention.
Main Results:
- Green tea polyphenols, especially EGCG, demonstrate significant anti-cancer activities.
- EGCG induces apoptosis, cell cycle arrest, and modulates immune responses (e.g., NF-kappa-B, IL-23).
- Green tea shows potential chemopreventive effects against colon, skin, lung, prostate, and breast cancers.
Conclusions:
- Green tea possesses potent antioxidant and immunomodulatory properties.
- EGCG is a major active component mediating cancer chemoprevention through various cellular pathways.
- Green tea represents a promising natural agent for cancer prevention and potentially adjunct therapy.
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