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Gastric microcirculation and its regulating factors in stress
M Kitajima1, A Shimizu, N Sakai
1Department of Surgery, School of Medicine, Keio University, Tokyo, Japan.
Journal of Clinical Gastroenterology
|January 1, 1991
Summary
Stress significantly reduces gastric mucosal blood flow, impacting superoxide dismutase and 5-hydroxytryptamine levels. This leads to gastric lesions via arteriovenular shunting and capillary hyperpermeability.
Area of Science:
- Gastroenterology
- Physiology
- Biochemistry
Background:
- Gastric mucosal integrity is vital for digestive health.
- Understanding factors affecting gastric blood flow is crucial for preventing lesions.
Purpose of the Study:
- To investigate the impact of stress on gastric mucosal blood flow.
- To identify the roles of 5-hydroxytryptamine (5-HT), CoQ10 anion radical, and superoxide dismutase (SOD) in stress-induced gastric changes.
Main Methods:
- Gastric mucosal blood flow measured using the hydrogen gas clearance method.
- Vascular patterns analyzed via silicon rubber infusion.
- CoQ10 anion radical and SOD levels quantified using electron spin resonance (ESR) and radioimmunoassay.
Main Results:
- Stress significantly decreased gastric mucosal blood flow early after induction.
- Impaired blood flow correlated with elevated 5-HT, CoQ10 anion radical, and SOD levels.
- Reduced blood flow was attributed to 5-HT-mediated arteriovenular shunt opening and capillary hyperpermeability.
Conclusions:
- Stress-induced reduction in gastric mucosal blood flow is a key factor in acute gastric lesion formation.
- 5-HT, CoQ10 anion radical, and SOD play significant roles in mediating these vascular changes.
- Ischemia and reperfusion following blood flow reduction precipitate the development of gastric mucosal lesions.