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Related Concept Videos

Peripheral Artery Disease V: Postoperative Nursing Management01:23

Peripheral Artery Disease V: Postoperative Nursing Management

During the postoperative period, it is crucial to focus on maintaining circulation, identifying and managing potential complications, and planning for discharge.Nursing AssessmentVital signs monitoring: Regularly monitor vital signs, including blood pressure, heart rate, respiratory rate, and temperature, to detect early signs of complications such as bleeding and infection.Circulation assessment: Monitor pulses, perform Doppler assessments, and check capillary refill, color, temperature, and...
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
Peripheral Artery Disease IV: Nursing Management01:26

Peripheral Artery Disease IV: Nursing Management

The nursing management of a patient with peripheral artery disease (PAD) begins with a thorough assessment of the patient’s health history and clinical manifestations.AssessmentHealth History: Evaluate the patient’s history of hypertension, hyperlipidemia, family history of cardiovascular issues, and lifestyle factors such as dietary patterns, smoking, and physical activity.Physical Examination:Assess the affected extremity for decreased or absent peripheral pulses, temperature changes,...
Peripheral Artery Disease III: Interprofessional Care01:27

Peripheral Artery Disease III: Interprofessional Care

Peripheral Artery Disease (PAD) is characterized by narrowed arteries that diminish blood flow to the extremities. Effective management of PAD requires an interprofessional approach involving various healthcare professionals. The critical aspects of interprofessional care for PAD patients focus on risk factor modification, drug therapy, exercise therapy, nutrition therapy, critical limb ischemia care, and interventional radiology and surgical procedures.The primary treatment goal for PAD...

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Regenerative Peripheral Nerve Interface: Surgical Protocol for a Randomized Controlled Trial in Postamputation Pain
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Published on: March 15, 2024

Post-stroke pain.

Jong S Kim1

  • 1Department of Neurology, University of Ulsan, Asan Medical Center, Seoul, Korea. jongskim@amc.seoul.kr

Expert Review of Neurotherapeutics
|May 1, 2009
PubMed
Summary
This summary is machine-generated.

Central post-stroke pain (CPSP) affects stroke survivors, causing significant quality of life issues. Current treatments are often insufficient, highlighting the need for better understanding and therapies for this challenging condition.

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Autoradiographic Measurements of [14C]-Iodoantipyrine in Rat Brain Following Central Post-Stroke Pain
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Autoradiographic Measurements of [14C]-Iodoantipyrine in Rat Brain Following Central Post-Stroke Pain

Published on: July 18, 2016

Area of Science:

  • Neurology
  • Pain Medicine
  • Stroke Rehabilitation

Background:

  • Post-stroke pain is a common and debilitating complication, affecting a significant percentage of stroke survivors.
  • Central post-stroke pain (CPSP), resulting directly from the brain lesion, presents unique challenges due to its persistent and often refractory nature.
  • The increasing aging population suggests CPSP will become a more prevalent issue, necessitating improved management strategies.

Purpose of the Study:

  • To review the current understanding of central post-stroke pain (CPSP) pathophysiology.
  • To summarize existing and emerging pharmacological and non-pharmacological treatment options for CPSP.
  • To emphasize the urgent need for further research into CPSP to enhance treatment efficacy.

Main Methods:

  • Literature review of studies on central post-stroke pain (CPSP).
  • Analysis of current treatment guidelines and emerging therapeutic approaches.
  • Synthesis of evidence regarding the pathophysiology and management of CPSP.

Main Results:

  • Central post-stroke pain (CPSP) pathogenesis remains unclear, with theories including sensory pathway hyperexcitation or impaired central inhibition.
  • First-line treatments like adrenergic antidepressants show incomplete efficacy.
  • Adjunctive therapies include antiepileptics (e.g., lamotrigine) and GABAergic drugs (e.g., gabapentin, pregabalin).
  • Non-pharmacological interventions like motor cortex stimulation and deep brain stimulation show promise in select patients.

Conclusions:

  • Central post-stroke pain (CPSP) is a significant challenge for stroke survivors, impacting quality of life.
  • Current therapeutic options offer limited relief, underscoring the need for novel treatment strategies.
  • Further research into CPSP pathophysiology is crucial for developing more effective interventions.