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Updated: Jun 23, 2026

Ookluc: A Plasmodium berghei Line for Identifying Transmission-blocking Compounds
Published on: July 11, 2025
Synthesis, antimalarial evaluation and molecular modeling studies of hydroxyethylpiperazines, potential aspartyl
Wilson Cunico1, Claudia R B Gomes, Victor Facchinetti
1Departamento de Síntese, Farmanguinhos-Fiocruz, R. Sizenando Nabuco 100, 21041-250 Rio de Janeiro, RJ, Brazil. wjcunico@yahoo.com.br
Abstract:
The antimalarial acitivity of hydroxyethylamines, synthesized from the reaction of intermediated hydroxyethypiperazines with benzenesulfonyl chlorides or benzoyl chlorides, has been evaluated in vitro against a W2 Plasmodium falciparum clone. Some of the nineteen tested derivatives showed a significant activity in vitro, thus turning into a promising new class of antimalarials. In addition, a molecular modeling study of the most active derivative (5l) was performed and its most probable binding modes within plasmepsin II enzyme were identified.
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