Related Experiment Video

Updated: Jun 23, 2026

A Patient-Derived Xenograft Model for Venous Malformation
06:51

A Patient-Derived Xenograft Model for Venous Malformation

Published on: June 15, 2020

From mutant mice to "vascular permeability therapy" in cavernous angiomas?

Issam A Awad

    Neurosurgery
    |May 1, 2009
    PubMed
    Summary

    No abstract available in PubMed .

    More Related Videos

    Evaluating Vascular Hyperpermeability-inducing Agents in the Skin with the Miles Assay08:43

    Evaluating Vascular Hyperpermeability-inducing Agents in the Skin with the Miles Assay

    Published on: June 19, 2018

    Adult Mouse Venous Hypertension Model: Common Carotid Artery to External Jugular Vein Anastomosis.08:27

    Adult Mouse Venous Hypertension Model: Common Carotid Artery to External Jugular Vein Anastomosis.

    Published on: January 27, 2015

    Related Concept Videos

    Mechanism of Angiogenesis01:10

    Mechanism of Angiogenesis

    Blood vessel formation starts early during embryonic development, around day 7. In the extraembryonic yolk sac, mesodermal precursor cells called hemangioblast proliferate and differentiate into angioblast. Angioblasts express vascular endothelial growth factor receptor 2 or VEGFR2, which binds VEGF-A, a proangiogenic factor, guiding blood vessel formation. VEGF signaling promotes angioblasts to form a blood island in the developing embryo. Angioblasts further differentiate, giving rise to...
    Regulation of Angiogenesis and Blood Supply01:24

    Regulation of Angiogenesis and Blood Supply

    Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl hydroxylase and factor...