Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Ophthalmic Drug Delivery for Noninvasive Neuromodulation in a Mouse Model02:37

Ophthalmic Drug Delivery for Noninvasive Neuromodulation in a Mouse Model

194
Source: Zhan, J., et al. Non-invasive Strategies for Chronic Manipulation of DREADD-controlled Neuronal Activity. J. Vis. Exp. (2019)This video demonstrates a non-invasive ophthalmic drug delivery method for targeted neuromodulation. The drug is delivered via eye drops, absorbed into the circulation, crosses the blood-brain barrier, and activates specific neuronal...
194
Fixation of Ultrasound Transducers for Spinal Cord Neuromodulation in Mice03:26

Fixation of Ultrasound Transducers for Spinal Cord Neuromodulation in Mice

699
This protocol describes an ultrasound transducer fixation system specifically designed for ultrasound stimulation of the spinal cord in awake mice. The method employs a fixation system to ensure accurate positioning of the ultrasound transducer while simultaneously allowing the experimental subjects to move freely without compromising the precision of...
699
Simultaneous Focused Ultrasound Neuromodulation and Fiber Photometry Recording in Free-Moving Mouse08:38

Simultaneous Focused Ultrasound Neuromodulation and Fiber Photometry Recording in Free-Moving Mouse

2.1K
The protocol includes transducer manufacturing, parameters reporting, surgical procedure, and signal recording for the entire operational workflow of concurrent focused ultrasound neuromodulation and fiber photometry recording in free-moving...
2.1K
Optogenetic Functional MRI06:06

Optogenetic Functional MRI

15.4K
This protocol describes the steps and data analysis required to successfully perform optogenetic functional magnetic resonance imaging (ofMRI). ofMRI is a novel technique that combines high-field fMRI readout with optogenetic stimulation, allowing for cell type-specific mapping of functional neural circuits and their dynamics across the whole living...
15.4K
Optogenetic Stimulation of the Auditory Nerve10:53

Optogenetic Stimulation of the Auditory Nerve

15.1K
Cochlear implants (CIs) enable hearing by direct electrical stimulation of the auditory nerve. However, poor frequency and intensity resolution limits the quality of hearing with CIs. Here we describe optogenetic stimulation of the auditory nerve in mice as an alternative strategy for auditory research and developing future CIs.
15.1K
Ultrasound-Induced Neuromodulation Using a Microelectrode Array System02:56

Ultrasound-Induced Neuromodulation Using a Microelectrode Array System

671
This video demonstrates the method for inducing the modulation of neural activity in cultured human iPSC-derived neurons in a multi-well microelectrode array, or MEA system using a focused ultrasound...
671

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Improved autobiographical memory with central thalamic deep brain stimulation in traumatic brain injury.

Brain communications·2026
Same author

A mosaic of whole-body representations on the human precentral gyrus.

Nature·2026
Same author

Neural decoding of speech using deep neural ensembles.

bioRxiv : the preprint server for biology·2026
Same author

Premotor cortex uses a compositional neural geometry to plan words.

bioRxiv : the preprint server for biology·2026
Same author

Cross-brain transfer of high-performance intracortical speech and handwriting BCIs.

bioRxiv : the preprint server for biology·2026
Same author

An algorithmic procedure for measuring deep brain stimulation-induced capsular activation using motor evoked potentials.

Journal of neural engineering·2025
Same journal

Performance of Risk Scores in Predicting Intracranial Aneurysm Instability.

Neurosurgery·2026
Same journal

Electric-Scooters: An Emerging Source of High-Severity Pediatric Head Trauma.

Neurosurgery·2026
Same journal

Survival After Surgery for Spinal Osteosarcoma and the Role of Chemotherapy and Treatment Sequencing: A National Cohort Multivariable Analysis.

Neurosurgery·2026
Same journal

Safety and Efficacy of 3-Month Versus 6-Month Duration of Dual Antiplatelet Therapy in Pipeline Embolization Treatment of Intracranial Aneurysms.

Neurosurgery·2026
Same journal

Risk Factors of Revision Surgery After Acute Proximal Junctional Fracture Following Adult Spinal Deformity Surgery.

Neurosurgery·2026
Same journal

Sensorimotor Network Alterations and Compensation in Cervical Spondylotic Myelopathy: A 7 T Task-Based and Resting-State Functional MRI Study.

Neurosurgery·2026
See all related articles

Related Experiment Video

Updated: Jan 19, 2026

Fixation of Ultrasound Transducers for Spinal Cord Neuromodulation in Mice
03:26

Fixation of Ultrasound Transducers for Spinal Cord Neuromodulation in Mice

Published on: August 1, 2025

699

Optogenetic neuromodulation.

Jaimie M Henderson1, Thais Federici, Nicholas Boulis

  • 1Department of Neurosurgery, Stanford University Medical Center, Stanford, California 94305, USA. henderj@stanford.edu

Neurosurgery
|May 1, 2009
PubMed
Summary
This summary is machine-generated.

Neuromodulation using optogenetics offers precise control over neural circuits by genetically engineering neurons for light sensitivity. This advanced technique overcomes limitations of traditional electrical and chemical methods for treating neurological diseases.

More Related Videos

Optogenetic Functional MRI
06:06

Optogenetic Functional MRI

Published on: April 19, 2016

15.4K
Ultrasound-Induced Neuromodulation Using a Microelectrode Array System
02:56

Ultrasound-Induced Neuromodulation Using a Microelectrode Array System

671

Related Experiment Videos

Last Updated: Jan 19, 2026

Fixation of Ultrasound Transducers for Spinal Cord Neuromodulation in Mice
03:26

Fixation of Ultrasound Transducers for Spinal Cord Neuromodulation in Mice

Published on: August 1, 2025

699
Optogenetic Functional MRI
06:06

Optogenetic Functional MRI

Published on: April 19, 2016

15.4K
Ultrasound-Induced Neuromodulation Using a Microelectrode Array System
02:56

Ultrasound-Induced Neuromodulation Using a Microelectrode Array System

671

Area of Science:

  • Neuroscience
  • Biotechnology
  • Medical Technology

Background:

  • Neuromodulation, using electrical or chemical means, is vital for treating neurological diseases.
  • Current methods like electrical stimulation lack specificity, causing side effects and limiting efficacy.
  • Optogenetics presents a novel approach to overcome these specificity challenges.

Purpose of the Study:

  • To review optogenetics as a precise neuromodulation tool.
  • To highlight the advantages of optogenetics over traditional techniques.
  • To illustrate potential applications in neurological disease treatment.

Main Methods:

  • Gene delivery to encode light-sensitive proteins in neurons.
  • Utilizing specific wavelengths of light to activate or inhibit targeted neuronal populations.
  • Review of existing literature and case studies on optogenetic applications.

Main Results:

  • Optogenetics enables highly specific modulation of neural circuits.
  • Light-activated neurons allow for precise control, unlike broad electrical stimulation.
  • Demonstrated potential for improved treatment efficacy with reduced side effects.

Conclusions:

  • Optogenetics offers unprecedented precision in neural circuit modulation.
  • This technology holds significant promise for advancing the treatment of neurological disorders.
  • Further research and application of optogenetics are expected to revolutionize neuromodulation therapies.