Fat(al) attraction: oxidized lipids act as "eat-me" signals

Phagocytosis of apoptotic cell corpses is a conserved and well-regulated process and is required to maintain tissue homeostasis within an organism. Evidence suggests that apoptotic cell engulfment by macrophages is dependent upon the externalization of phosphatidylserine (PS) on the plasma membrane of the dying cell. Furthermore, oxidation of PS and other phospholipids may serve to facilitate cell corpse removal. However, our understanding of how these various lipid "eat-me" signals are recognized by macrophages has been limited. Using a combination of cellular and animal models, along with an array of biophysical methods, Hazen and his associates (Greenberg et al., J. Exp. Med., 2006, 203, 2613-2625;Li et al., Biochemistry, 2007, 46, 5009-5017) have now identified the scavenger receptor CD36 as a putative receptor for oxidized PS on apoptotic cells; moreover, they have deduced the conformation of the oxidized lipid ligand that is recognized by this receptor, thus providing structural insight into how phagocytes recognize senescent or apoptotic cells.