Related Experiment Video

Updated: Jun 23, 2026

Real-time Imaging of Myeloid Cells Dynamics in ApcMin/+ Intestinal Tumors by Spinning Disk Confocal Microscopy
05:21

Real-time Imaging of Myeloid Cells Dynamics in ApcMin/+ Intestinal Tumors by Spinning Disk Confocal Microscopy

Published on: October 6, 2014

Mechanical factors activate beta-catenin-dependent oncogene expression in APC mouse colon

Joanne Whitehead, Danijela Vignjevic, Claus Fütterer

    HFSP Journal
    |May 1, 2009
    PubMed
    Summary

    Mechanical stress can trigger colon cancer initiation in preneoplastic tissues by activating beta-catenin signaling. This mechanical activation of oncogenes like Myc and Twist1 is preventable with Src kinase inhibitors.

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