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Related Concept Videos

M-Cdk Drives Transition Into Mitosis02:15

M-Cdk Drives Transition Into Mitosis

Checkpoints throughout the cell cycle serve as safeguards and gatekeepers, allowing the cell cycle to progress in favorable conditions and slow or halt it in problematic ones. This regulation is known as the cell cycle control system.
Cyclin-dependent kinases, or Cdks, work in concert with cyclins to control cell cycle transitions. M-Cdk, a complex of Cdk1 bound to M cyclin, is a well-known example of this coordinated control that drives the transition from the G2 to the M phase.
M cyclin...
M-Cdk Drives Transition Into Mitosis02:15

M-Cdk Drives Transition Into Mitosis

Checkpoints throughout the cell cycle serve as safeguards and gatekeepers, allowing the cell cycle to progress in favorable conditions and slow or halt it in problematic ones. This regulation is known as the cell cycle control system.
Cyclin-dependent kinases, or Cdks, work in concert with cyclins to control cell cycle transitions. M-Cdk, a complex of Cdk1 bound to M cyclin, is a well-known example of this coordinated control that drives the transition from the G2 to the M phase.
M cyclin...
Mitosis and Cytokinesis01:35

Mitosis and Cytokinesis

In eukaryotes, the cell division cycle is divided into distinct, coordinated cellular processes that include cell growth, DNA replication/chromosome duplication, chromosome distribution to daughter cells, and finally, cell division. The cell cycle is tightly regulated by its regulatory systems as well as extracellular signals that affect cell proliferation.
The processes of the cell cycle occur over approximately 24 hours (in typical human cells) and in two major distinguishable stages. The...
Mitosis And Cytokinesis01:35

Mitosis And Cytokinesis

In eukaryotes, the cell division cycle is divided into distinct, coordinated cellular processes that include cell growth, DNA replication/chromosome duplication, chromosome distribution to daughter cells, and finally, cell division. The cell cycle is tightly regulated by its regulatory systems as well as extracellular signals that affect cell proliferation.
The processes of the cell cycle occur over approximately 24 hours (in typical human cells) and in two major distinguishable stages. The...
Mitosis and Cytokinesis02:03

Mitosis and Cytokinesis

In eukaryotes, the cell division cycle is divided into distinct, coordinated cellular processes that include cell growth, DNA replication/chromosome duplication, chromosome distribution to daughter cells, and finally, cell division. The cell cycle is tightly regulated by its regulatory systems as well as extracellular signals that affect cell proliferation.
The processes of the cell cycle occur over approximately 24 hours (in typical human cells) and in two major distinguishable stages. The...
Mitosis and Cytokinesis02:03

Mitosis and Cytokinesis

In eukaryotes, the cell division cycle is divided into distinct, coordinated cellular processes that include cell growth, DNA replication/chromosome duplication, chromosome distribution to daughter cells, and finally, cell division. The cell cycle is tightly regulated by its regulatory systems as well as extracellular signals that affect cell proliferation.
The processes of the cell cycle occur over approximately 24 hours (in typical human cells) and in two major distinguishable stages. The...

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Updated: Jun 23, 2026

Examination of Mitotic and Meiotic Fission Yeast Nuclear Dynamics by Fluorescence Live-cell Microscopy
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Examination of Mitotic and Meiotic Fission Yeast Nuclear Dynamics by Fluorescence Live-cell Microscopy

Published on: June 24, 2019

Get round and stiff for mitosis.

Manuel Théry, Michel Bornens

    HFSP Journal
    |May 1, 2009
    PubMed
    Summary
    This summary is machine-generated.

    Cells round up during division through a complex mechanical process, not simple softening. Understanding the links between the cell membrane and cytoskeleton is key to cell division.

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    Area of Science:

    • Cell Biology
    • Biophysics
    • Mechanobiology

    Background:

    • Cell rounding is a fundamental event during cell division (mitosis).
    • This shape change is a complex mechanical process, not merely passive softening or stiffening.
    • It involves intricate membrane dynamics and cytoskeletal interactions.

    Purpose of the Study:

    • To elucidate the mechanical mechanisms underlying cell rounding during mitosis.
    • To highlight the importance of membrane-cytoskeleton interactions in cell division.
    • To provide new insights into the regulation of cell shape during cell division.

    Main Methods:

    • Investigated the physical and mechanical transformations cells undergo during division.
    • Focused on the role of membrane folding and peripheral signaling.
    • Examined the connection between the lipid bilayer membrane and the actin cytoskeleton.

    Main Results:

    • Cell rounding is an active, complex mechanical transformation, not a passive equilibrium.
    • Membrane folding and peripheral signal focusing are crucial for matching spindle size.
    • Physical links between the membrane and actin cytoskeleton are critical regulators.

    Conclusions:

    • The regulation of membrane-cytoskeleton physical links is vital for proper cell division.
    • New insights emphasize the importance of biophysical mechanisms in cell division.
    • Future research should focus on these physical links to understand cell division events.