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Related Concept Videos

Drugs for Treatment of Diarrhea-Predominant IBS01:17

Drugs for Treatment of Diarrhea-Predominant IBS

Diarrhea-predominant irritable bowel syndrome (IBS-D) is a subtype of IBS characterized primarily by frequent, loose, or watery stools, abdominal pain, and abdominal discomfort. Therapeutic approaches to managing IBS-D include dietary changes, stress management techniques, and pharmaceutical interventions.
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
Drugs Affecting GI Tract Motility: Dopamine Receptor Antagonists01:28

Drugs Affecting GI Tract Motility: Dopamine Receptor Antagonists

Prokinetic agents are specialized medications that stimulate gastrointestinal (GI) motility, promoting food movement through the GI tract. Dopamine, an inhibitory neurotransmitter, plays a significant role in this process, reducing GI motility and indirectly controlling the speed of digestion. Dopamine receptor antagonists, such as metoclopramide and domperidone, offer a unique advantage as prokinetic agents. By blocking the dopamine receptors, these drugs increase GI motility, improving food...
Drugs for Treatment of Constipation-Predominant IBS01:21

Drugs for Treatment of Constipation-Predominant IBS

Pharmacological therapies for IBS-C are designed to alleviate abdominal discomfort and enhance bowel function. In patients with IBS-C, fiber supplements may help soften stools and decrease straining, but may also lead to increased gas production and bloating. Osmotic laxatives like milk of magnesia are frequently used to soften stools and increase stool frequency in IBS-C patients. In addition, two drugs approved for use in severe IBS-C adult cases are linaclotide (Linzess) and lubiprostone...
Drugs Affecting GI Tract Motility: Serotonin Receptor Agonists01:23

Drugs Affecting GI Tract Motility: Serotonin Receptor Agonists

Serotonin, a crucial neurotransmitter synthesized by enterochromaffin cells, plays a cardinal role in regulating gastrointestinal (GI) motility. With over 90% of the body's total serotonin in the GI tract, its influence on digestive processes is profound. Serotonin is swiftly released upon various stimuli, such as food boluses or certain drugs, triggering intrinsic sensory neurons in the myenteric plexus and extrinsic vagal and spinal sensory neurons. This leads to the activation of the...
Direct-Acting Cholinergic Agonists: Therapeutic Uses01:11

Direct-Acting Cholinergic Agonists: Therapeutic Uses

Direct-acting cholinergic agonists have many therapeutic uses in various medical fields. Choline esters, including acetylcholine, have limited clinical utility due to their non-selectivity and short duration of action. Still, acetylcholine and carbachol are applied topically during ophthalmologic surgery to induce miosis. Pilocarpine, a muscarinic and ganglionic stimulator, effectively treats open-angle glaucoma and alleviates xerostomia and dry mouth caused by radiotherapy or Sjögren syndrome.
Adrenergic Agonists: Direct-Acting Agents01:30

Adrenergic Agonists: Direct-Acting Agents

Drugs that mimic the action of endogenous catecholamines like noradrenaline and adrenaline are called adrenergic agonists or sympathomimetics. Based on their mechanism of action, sympathomimetics can be classified as direct-, indirect-, or mixed-acting sympathomimetics. Direct-acting adrenergic agonists activate adrenoceptors without affecting presynaptic neurons, making them independent of neuronal catecholamine-depleting agents like reserpine and guanethidine.
These agents can be classified...

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Related Experiment Videos

Fesoterodine.

Kate McKeage1, Gillian M Keating

  • 1Wolters Kluwer Health mid R: Adis, Auckland, New Zealand, an editorial office of Wolters Kluwer Health, Philadelphia, Pennsylvania, USA. demail@adis.co.nz

Drugs
|May 2, 2009
PubMed
Summary
This summary is machine-generated.

Fesoterodine effectively treats overactive bladder (OAB) symptoms like urgency and incontinence. Clinical trials show significant improvement in OAB patients compared to placebo, with good tolerability.

Related Experiment Videos

Area of Science:

  • Pharmacology
  • Urology

Background:

  • Fesoterodine is a muscarinic receptor antagonist.
  • It is rapidly converted to its active metabolite, 5-hydroxymethyltolterodine.
  • Fesoterodine is approved for treating overactive bladder (OAB) via once-daily oral administration.

Purpose of the Study:

  • To evaluate the efficacy and safety of oral fesoterodine in patients with overactive bladder syndrome (OAB).

Main Methods:

  • Two large, 12-week, randomized, double-blind, multicentre, phase III trials were conducted.
  • Patients received either oral fesoterodine (4 or 8 mg once daily) or a placebo.
  • Efficacy was assessed by OAB symptom improvement and patient-reported treatment response.

Main Results:

  • Oral fesoterodine (4 or 8 mg once daily) significantly improved OAB symptoms (frequency, urgency, urge incontinence) compared to placebo.
  • A higher proportion of patients on fesoterodine reported a positive treatment response.
  • Health-related quality of life significantly improved in the fesoterodine group.

Conclusions:

  • Once-daily oral fesoterodine is an effective treatment for overactive bladder syndrome.
  • The drug demonstrates significant improvements in OAB symptoms and quality of life.
  • Fesoterodine was generally well-tolerated, with dry mouth being the most common side effect.