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Sensing of Barrier Tissue Disruption with an Organic Electrochemical Transistor
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Published on: February 10, 2014

Regulation of epithelial apical junctions and barrier function by Galpha13

Rino Donato1, Stephen A Wood, Ian Saunders

  • 1Women's and Children's Health Research Institute, North Adelaide, South Australia, Australia.

Biochimica Et Biophysica Acta
|May 2, 2009
PubMed
Summary

The heterotrimeric G-protein Galpha13 disrupts epithelial tight junctions, increasing permeability. Rho kinase signaling mediates these effects, distinct from Galpha12 pathways, impacting epithelial barrier function.

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