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Updated: Jun 23, 2026

Dynamic Contrast Enhanced Magnetic Resonance Imaging of an Orthotopic Pancreatic Cancer Mouse Model
Published on: April 18, 2015
Fundamentals of quantitative dynamic contrast-enhanced MR imaging
Michael J Paldino1, Daniel P Barboriak
1Division of Neuroradiology, Department of Radiology, Duke University Medical Center, Box 3808, Erwin Road, Durham, NC 27710, USA. paldi001@mc.duke.edu
Abstract:
Quantitative analysis of dynamic contrast-enhanced MR imaging (DCE-MR imaging) has the power to provide information regarding physiologic characteristics of the microvasculature and is, therefore, of great potential value to the practice of oncology. In particular, these techniques could have a significant impact on the development of novel anticancer therapies as a promising biomarker of drug activity. Standardization of DCE-MR imaging acquisition and analysis to provide more reproducible measures of tumor vessel physiology is of crucial importance to realize this potential. The purpose of this article is to review the pathophysiologic basis and technical aspects of DCE-MR imaging techniques.
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