Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

In Vitro Fertilization01:24

In Vitro Fertilization

In vitro fertilization (IVF) is a form of assisted reproductive technology where an egg is fertilized with sperm in a controlled laboratory environment before transferring the resulting embryo into the uterus. This process is designed to help individuals and couples experiencing difficulties conceiving.
The IVF process begins with ovarian stimulation, during which reproductive endocrinologists prescribe hormonal medications to stimulate the ovaries to produce multiple eggs instead of the single...
Local Anesthetics: Clinical Application as Epidural Anesthesia01:29

Local Anesthetics: Clinical Application as Epidural Anesthesia

Epidural anesthetics are administered in the fat-filled epidural space, the outermost part of the spinal canal. This technique is commonly employed for pain management and anesthesia during lower abdomen and pelvis surgeries or labor and delivery.
Since epidural anesthetics can be infused through an epidural catheter, all types of drugs, including short-acting ones, can be administered. Chloroprocaine and lidocaine are examples of short and long-duration anesthetics, respectively. Bupivacaine...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

<i>SPP1</i><sup>hi</sup> macrophages in fibrin niches promote hyperplastic tissue remodeling in rheumatoid arthritis synovium.

Science translational medicineĀ·2026
Same author

scLASER: a robust framework for simulating and detecting time-dependent single-cell dynamics in longitudinal studies.

bioRxiv : the preprint server for biologyĀ·2026
Same author

Cannabis Use and the Risk of Arrhythmias: Insights From a Large Retrospective Multicenter Analysis.

Journal of cardiovascular electrophysiologyĀ·2025
Same author

Heart's Hidden Signal: A Rare Case of Alternating Bundle Branch Block and Atrioventricular Block.

JACC. Case reportsĀ·2025
Same author

Society of Family Planning Clinical Recommendation: Induction of fetal asystole before abortion Jointly developed with the Society for Maternal-Fetal Medicine<sup>ā˜†</sup><sup>,</sup><sup>ā˜†ā˜†</sup>.

American journal of obstetrics and gynecologyĀ·2024
Same author

Fish tank granuloma not associated to Mycobacterium marinum but to Microbacterium paraoxydans.

Revista medica de ChileĀ·2024
Same journal

Dissecting the Americans With Disabilities Act (ADA) Requirements when Approaching Obstetric Patients With Disabilities: How to Ensure Your Spaces are Accessible for All.

Clinical obstetrics and gynecologyĀ·2026
Same journal

Clinician Comfort and Barriers to the Obstetric and Gynecologic Care of Patients With Disabilities.

Clinical obstetrics and gynecologyĀ·2026
Same journal

Obstetric Care for Patients With Visual Impairments: Preconception Counseling Through Postpartum Care.

Clinical obstetrics and gynecologyĀ·2026
Same journal

Menstrual Management and Contraception for Patients With Disabilities.

Clinical obstetrics and gynecologyĀ·2026
Same journal

Favoring Elective Hospitalization in Pregnancies With Vasa Previa.

Clinical obstetrics and gynecologyĀ·2026
Same journal

Against Recommending History Indicated Cerclage.

Clinical obstetrics and gynecologyĀ·2026
See all related articles

Related Experiment Video

Updated: Jun 23, 2026

Continuous Telemetric In Utero Tracheal Pressure Measurements in Fetal Lambs
05:40

Continuous Telemetric In Utero Tracheal Pressure Measurements in Fetal Lambs

Published on: December 22, 2023

Second-trimester induction of labor.

Juan Vargas1, Justin Diedrich

  • 1Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, CA 94110, USA. vargasj@obgyn.ucsf.edu

Clinical Obstetrics and Gynecology
|May 2, 2009
PubMed
Summary
This summary is machine-generated.

Second-trimester abortions often use dilation and evacuation, but medication abortion is sometimes necessary. Misoprostol-only regimens are less effective and have more side effects than mifepristone-misoprostol combinations for late-term abortions.

More Related Videos

Mouse In Vivo Placental Targeted CRISPR Manipulation
07:39

Mouse In Vivo Placental Targeted CRISPR Manipulation

Published on: April 14, 2023

Intrauterine Telemetry to Measure Mouse Contractile Pressure In Vivo
07:03

Intrauterine Telemetry to Measure Mouse Contractile Pressure In Vivo

Published on: April 6, 2015

Related Experiment Videos

Last Updated: Jun 23, 2026

Continuous Telemetric In Utero Tracheal Pressure Measurements in Fetal Lambs
05:40

Continuous Telemetric In Utero Tracheal Pressure Measurements in Fetal Lambs

Published on: December 22, 2023

Mouse In Vivo Placental Targeted CRISPR Manipulation
07:39

Mouse In Vivo Placental Targeted CRISPR Manipulation

Published on: April 14, 2023

Intrauterine Telemetry to Measure Mouse Contractile Pressure In Vivo
07:03

Intrauterine Telemetry to Measure Mouse Contractile Pressure In Vivo

Published on: April 6, 2015

Area of Science:

  • Obstetrics and Gynecology
  • Reproductive Health
  • Medical Abortion

Background:

  • Second-trimester abortions (14-24 weeks) are frequently performed via dilation and evacuation (D&E).
  • Systemic abortifacients are sometimes necessary due to factors like staff training, fetal anomalies, or patient preference.
  • Medical induction methods are crucial alternatives for late-term pregnancy termination.

Purpose of the Study:

  • To review medical induction methods for second-trimester abortions in the United States.
  • To compare the efficacy and side effects of different medication regimens.
  • To highlight considerations for selecting abortion procedures after 14 weeks of gestation.

Main Methods:

  • Review of medical induction protocols for abortions between 14 and 24 weeks of gestation.
  • Comparison of misoprostol-only protocols versus mifepristone-misoprostol combinations.
  • Discussion of the role of feticidal agents in late-term abortions.

Main Results:

  • Misoprostol-only protocols for second-trimester abortions require higher doses and have more side effects.
  • Mifepristone-misoprostol combinations are generally more effective and faster than misoprostol-only regimens.
  • Feticidal agents are recommended to prevent transient fetal survival during medical induction.

Conclusions:

  • Medical induction is a viable option for second-trimester abortions when D&E is not preferred or feasible.
  • Mifepristone-misoprostol combinations offer advantages over misoprostol-only protocols in terms of efficacy and side effect profile.
  • Careful patient selection and consideration of factors like fetal anomalies are essential for successful pregnancy termination.