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Fluorenone alkaloid from Caulophyllum robustum Maxim. with anti-myocardial ischemia activity
Sicen Wang1, Binyu Wen, Na Wang
1School of Medicine, Xi'an Jiaotong University, Xi'an, Shaanxi, 710061, People's Republic of China.
Archives of Pharmacal Research
|May 2, 2009
Abstract:
A new fluorenone alkaloid (caulophine) was isolated from the radix of Caulophyllum robustum Maxim. (collected from the Qinling mountains) using cell membrane chromatography as the screening method. Caulophine was identified as 3-(2-(dimethylamino)ethyl)-4,5-dihydroxy-1,6-dimethoxy-9H-fluoren-9-one based on physicochemic and spectroscopic analyses, particularly by NMR spectroscopic data (i.e., COSY, HMQC, HMBC, NOESY). Caulophine possessed anti-myocardial ischemia activity.