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Updated: Jun 23, 2026

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Rapid One-step Enzymatic Synthesis and All-aqueous Purification of Trehalose Analogues
Published on: February 17, 2017
Total synthesis of (-)-talaumidin and (-)-galbelgin
Peng Xue1, Li-Ping Wang, Xiao-Zhen Jiao
1Peking Union Medical College and Chinese Academy of Medical Sciences, Institute of Materia Medica, Beijing, China.
Journal of Asian Natural Products Research
|May 2, 2009
Abstract:
( - )-Talaumidin (1) and ( - )-galbelgin (2) have been synthesized via 4-pentenoic acid as a starting material with the overall yield of about 17.8 and 16.9%, respectively. The key steps include Evans asymmetry anti-aldol reaction, TBS protection, hydroboration, oxidation, Friedel-Crafts arylation, etc.

