Screening tests of platelet function: update on their appropriate uses for diagnostic testing

Area of Science:

• Hematology
• Clinical Pathology

Background:

• Global platelet function tests are frequently used in diagnosing hemostatic defects.
• These tests are part of a two-step diagnostic strategy, requiring specialized assays for definitive diagnosis.
• The primary rationale for using global tests is to potentially rule out platelet function disorders, avoiding further testing.

Purpose of the Study:

• To review the limitations of commonly used global platelet function tests.
• To discuss the role of template bleeding time and Platelet Function Analyzer closure time in screening for platelet disorders.

Main Methods:

• Review of existing literature on global platelet function tests.
• Detailed consideration of template bleeding time and Platelet Function Analyzer closure time.

Main Results:

• Global tests of platelet function do not provide specific diagnoses.
• Template bleeding time and Platelet Function Analyzer closure time are widely used screening methods.
• Limitations exist in using these global tests for accurate screening of platelet disorders.

Conclusions:

• Global platelet function tests serve as initial screening but lack diagnostic specificity.
• Further specialized assays are necessary to confirm or refute platelet function disorders.
• Understanding the limitations of screening tests is crucial for effective diagnosis.