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Related Experiment Video

Updated: Jun 23, 2026

HKUST-1 as a Heterogeneous Catalyst for the Synthesis of Vanillin

HKUST-1 as a Heterogeneous Catalyst for the Synthesis of Vanillin

Published on: July 23, 2016

Spectrophotometric determination of tranexamic acid using vanillin.

E M A Rind¹, M G H Laghari, A H Memon

¹Faculty of Pharmacy, University of Sindh, Jamshoro, Pakistan. mahboobalirind@yahoo.com

Yao Xue Xue Bao = Acta Pharmaceutica Sinica

|May 5, 2009

Summary

A new spectrophotometric method accurately determines tranexamic acid (TA) using vanillin. This stable method is effective for analyzing TA in pharmaceutical products like capsules, injections, and toothpastes.

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Area of Science:

Analytical Chemistry
Pharmaceutical Analysis

Background:

Tranexamic acid (TA) is a crucial antifibrinolytic agent.
Accurate quantification of TA in pharmaceutical formulations is essential for quality control.

Purpose of the Study:

To develop and validate a novel spectrophotometric method for tranexamic acid determination.
To assess the applicability of the method for analyzing TA in various pharmaceutical products.

Main Methods:

Spectrophotometric analysis utilizing derivatization with vanillin (VAN).
Determination of molar absorptivity and adherence to Beer's Law within a specified concentration range.
Stability assessment of the color reaction over time.

Main Results:

Molar absorptivity of TA determined as 25,160 L x mol(-1) x cm(-1) at 354 nm.
Beer's Law adherence observed between 0.5-2.5 microg x mL(-1).
The developed method successfully quantified TA in capsules, injections, and toothpastes with low relative standard deviation (0.2%-5.0%).

Conclusions:

The vanillin derivatization spectrophotometric method provides a reliable and stable approach for tranexamic acid quantification.
The method is suitable for routine quality control analysis of tranexamic acid in diverse pharmaceutical dosage forms.