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Related Experiment Video

Updated: Jun 23, 2026

Plasmonic Trapping and Release of Nanoparticles in a Monitoring Environment
09:13

Plasmonic Trapping and Release of Nanoparticles in a Monitoring Environment

Published on: April 4, 2017

Nanoholes as nanochannels: flow-through plasmonic sensing.

Fatemeh Eftekhari1, Carlos Escobedo, Jacqueline Ferreira

  • 1Electrical and Computer Engineering, University of Victoria, Victoria, British Columbia, Canada.

Analytical Chemistry
|May 5, 2009
PubMed
Summary

This study introduces a novel flow-through nanohole array for surface-plasmon resonance (SPR) biosensing, enhancing speed and efficiency. The new method shows a 6-fold faster response time for detecting biomarkers.

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Area of Science:

  • Nanotechnology
  • Biomedical Engineering
  • Analytical Chemistry

Background:

  • Surface-plasmon resonance (SPR) sensing utilizes nanohole arrays for biosensing applications.
  • Existing research primarily uses dead-ended nanohole designs, limiting transport efficiency.
  • Nanoconfined transport combined with SPR sensing offers potential for improved biosensor performance.

Purpose of the Study:

  • To develop and evaluate a flow-through nanohole array system for enhanced SPR biosensing.
  • To leverage nanoconfined transport for rapid reactant delivery and improved biomarker detection.
  • To compare the performance of the flow-through method against traditional flow-over techniques.

Main Methods:

  • Integration of nanofluidics and nanoplasmonics to create flow-through nanohole arrays.

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  • Utilizing surface plasmons for resonant transmission in nanohole arrays.
  • Real-time monitoring of monolayer formation and antibody immobilization using the flow-through system.

    • Main Results:

    • The flow-through nanohole array demonstrated efficient transport of reactants to the sensing surface.
    • Successful real-time monitoring of biomolecular interactions, including antibody immobilization.
    • Achieved a 6-fold improvement in response time compared to the conventional flow-over method.

    Conclusions:

    • Flow-through nanohole arrays represent a significant advancement in SPR biosensing technology.
    • This approach offers enhanced speed and efficiency for biomarker detection and analysis.
    • The developed method holds promise for improved diagnostic tools and time-of-analysis in biosensing applications.