Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Insulin: Dosing Regimen and Adverse Effects01:16

Insulin: Dosing Regimen and Adverse Effects

Insulin-replacement therapy usually includes both long-acting insulin (basal) and short-acting insulin (to cater to postprandial needs). In a diverse group of type 1 diabetes patients, the average daily insulin dose is typically 0.5-0.7 units/kg body weight. However, obese patients and pubertal adolescents may need more due to insulin resistance.
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
Diabetes Mellitus: Overview and Type I Subtype01:22

Diabetes Mellitus: Overview and Type I Subtype

Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Type I Diabetes I: Introduction01:12

Type I Diabetes I: Introduction

Type 1 diabetes mellitus is a chronic metabolic disorder characterized by an absolute deficiency of insulin resulting from the autoimmune destruction of pancreatic β-cells. Although it can occur at any age, it is most commonly diagnosed in childhood, adolescence, or early adulthood. The loss of insulin production impairs cellular glucose uptake, resulting in persistent hyperglycemia and necessitating lifelong insulin therapy.Autoimmune Destruction of β-CellsThe hallmark of type 1 diabetes is an...
Type I Diabetes III: Clinical Manifestations01:19

Type I Diabetes III: Clinical Manifestations

Type 1 diabetes mellitus typically presents with rapid-onset symptoms due to the body’s inability to utilize glucose in the absence of insulin. Since insulin is required for glucose uptake into cells, its deficiency leads to hyperglycemia and cellular energy deprivation, resulting in characteristic clinical features.Polyuria and PolydipsiaOne of the earliest, most prominent symptoms is polyuria (excessive urination). When blood glucose concentrations rise above the renal threshold, the kidneys...
Type I Diabetes II: Pathophysiology01:26

Type I Diabetes II: Pathophysiology

Type 1 diabetes mellitus arises from an immune-mediated destruction of pancreatic β-cells, resulting in an absolute deficiency of insulin. This process develops in genetically susceptible individuals when autoimmunity, environmental exposures, and immunologic dysregulation converge to trigger a targeted attack on the insulin-producing cells of the pancreas. The β-cells are located within the islets of Langerhans and are essential for regulating blood glucose by facilitating cellular uptake of...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Transcervical drainage of abdominal-pelvic abscess after laparoscopic sacrocolpopexy.

International urogynecology journal·2020
Same author

Successful Treatment of Hypocomplementemic Urticarial Vasculitis With Omalizumab: A Case Report.

Journal of investigational allergology & clinical immunology·2020
Same author

Antimicrobial activity of Chlorhexidine, Peracetic acid and Sodium hypochlorite/etidronate irrigant solutions against Enterococcus faecalis biofilms.

International endodontic journal·2014
Same author

[Terrestrial rabies alert in Spain in 2013. Paediatric update].

Anales de pediatria (Barcelona, Spain : 2003)·2014
Same author

[Validation of a nutritional screening tool for hospitalized pediatric patients].

Nutricion hospitalaria·2013
Same author

[Tetany secondary to deficiency rickets].

Nutricion hospitalaria·2012

Related Experiment Video

Updated: Jun 23, 2026

Accelerated Type 1 Diabetes Induction in Mice by Adoptive Transfer of Diabetogenic CD4+ T Cells
06:27

Accelerated Type 1 Diabetes Induction in Mice by Adoptive Transfer of Diabetogenic CD4+ T Cells

Published on: May 6, 2013

[Final size attained in type 1 diabetes children].

R Galera Martínez1, E García García, M D Gámez Gómez

  • 1Unidad de Endocrinología Infantil, Servicio de Pediatría, Hospital Torrecárdenas, Almería, España. r.galera@yahoo.es

Anales De Pediatria (Barcelona, Spain : 2003)
|May 5, 2009
PubMed
Summary

Children with type 1 diabetes mellitus experienced growth reduction, especially prepubertal boys. Poorer metabolic control, indicated by glycated haemoglobin, correlated with reduced height gain in both sexes.

Related Experiment Videos

Last Updated: Jun 23, 2026

Accelerated Type 1 Diabetes Induction in Mice by Adoptive Transfer of Diabetogenic CD4+ T Cells
06:27

Accelerated Type 1 Diabetes Induction in Mice by Adoptive Transfer of Diabetogenic CD4+ T Cells

Published on: May 6, 2013

Area of Science:

  • Pediatric Endocrinology
  • Metabolic Disorders
  • Growth and Development

Context:

  • Type 1 diabetes mellitus (T1DM) diagnosis in childhood can impact growth.
  • Understanding final height and height gain is crucial for long-term health outcomes.

Purpose:

  • To evaluate final height and height gain in children with T1DM relative to target height.
  • To analyze the relationship between growth parameters and variables like metabolic control (HbA1c), insulin dose, and BMI.

Summary:

  • Children with T1DM were initially taller than average, but experienced growth reduction during disease progression, particularly prepubertal boys.
  • Final height was slightly below average in boys and similar to the general population in girls. Height gain was less in boys.
  • Mean glycated haemoglobin (HbA1c) was the sole significant predictor of reduced height gain, with a 2 cm reduction for every 1% increase.

Impact:

  • Highlights the negative impact of T1DM and suboptimal metabolic control on growth in children.
  • Provides valuable data for pediatric endocrinologists managing T1DM, emphasizing the importance of glycemic control for growth.
  • Informs clinical practice regarding growth monitoring and management strategies for children with T1DM.