Related Experiment Video
Updated: Jun 23, 2026

Measurement of Fatty Acid β-Oxidation in a Suspension of Freshly Isolated Mouse Hepatocytes
Published on: September 9, 2021
Influence of Helicteres isora administration for diabetes mellitus: the effect on changes in tissue fatty acid
G Kumar1, Sharmila Banu, A G Murugesan
1Manonmaniam Sundaranar University, Sri Paramakalyani Centre for Environmental Sciences, Alwarkurichi, Tamilnadu 627 412, India. pgsvedhakumar@yahoo.com
Abstract:
The aim of the present study was to evaluate the effect of aqueous bark extract of Helicteres isora (HI) (Sterculiaceae) on the blood glucose, plasma insulin and fatty acid composition of the total lipids in the liver, kidney and brain of control and streptozotocin (STZ) diabetic rats. The analysis of fatty acids showed that there was a significant increase in the concentrations of palmitic acid (16:1), stearic acid (18:0) and oleic acid (18:1) in the liver, kidney and brain, whereas the concentrations of linolenic acid (18:3) and arachidonic acid (20:4) were significantly decreased in STZ diabetic rats. Oral administration of the aqueous bark extract of HI (100, 200mg/kg body weight) for 30 days to diabetic rats decreased the concentrations of fatty acids, viz., palmitic, stearic, and oleic acid, whereas linolenic and arachidonic acid were elevated. These results suggest that HI exhibits antidiabetic and antihyperlipidemic effects in STZ induced diabetic rats. It also prevents the fatty acid changes produced during diabetes. The antidiabetic and antihyperlipidemic effects of HI are more potent than those of tolbutamide, as standard drug. The results of the present study indicate that HI showed an antihyperlipidemic effect in addition to its antidiabetic effect in type 2 diabetic rats.
Related Concept Videos
Oral Hypoglycemic Agents: α-Glucosidase Inhibitors
Acarbose and miglitol are typically...
Insulin: Dosing Regimen and Adverse Effects
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
Dipeptidyl Peptidase 4 Inhibitors
Type II Diabetes II: Pathophysiology
Hypoglycemia
Atherosclerosis III: Management
