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Related Experiment Video

Updated: Jun 23, 2026

Real-Time Cardiac Mapping with a Noninvasive Imageless Electrocardiographic Imaging System
10:17

Real-Time Cardiac Mapping with a Noninvasive Imageless Electrocardiographic Imaging System

Published on: April 11, 2025

Cardiac activation mapping using ultrasound current source density imaging (UCSDI).

Ragnar Olafsson1, Russell S Witte, Congxian Jia

  • 1Biomedical Engineering Department, University of Michigan, Ann Arbor, MI, USA.

IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
|May 5, 2009
PubMed
Summary

This study introduces ultrasound current source density imaging (UCSDI) for mapping cardiac electrical activity. UCSDI offers a promising new method for visualizing biological current flow in the heart with improved resolution.

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Last Updated: Jun 23, 2026

Real-Time Cardiac Mapping with a Noninvasive Imageless Electrocardiographic Imaging System
10:17

Real-Time Cardiac Mapping with a Noninvasive Imageless Electrocardiographic Imaging System

Published on: April 11, 2025

Ultrasonic Assessment of Myocardial Microstructure
10:53

Ultrasonic Assessment of Myocardial Microstructure

Published on: January 14, 2014

Area of Science:

  • Biophysics
  • Cardiovascular Physiology
  • Medical Imaging

Background:

  • Cardiac arrhythmias necessitate precise mapping of the electrical activation wave for effective ablation.
  • Current mapping methods suffer from time-consuming procedures and limited spatial resolution (5-10 mm).

Purpose of the Study:

  • To present the first application of ultrasound current source density imaging (UCSDI) for mapping biological current in a live heart.
  • To evaluate UCSDI's potential to overcome limitations of conventional cardiac mapping techniques.

Main Methods:

  • Utilized the acousto-electric (AE) effect, a pressure-induced resistivity change confined to the ultrasound focus.
  • Scanned a 540 kHz ultrasonic transducer over an isolated rabbit heart, recording AE signals and ECG simultaneously with tungsten electrodes.
  • Employed an excitation-contraction decoupler to minimize motion while preserving cardiac electrical function.

Main Results:

  • UCSDI successfully displayed spatial and temporal patterns of the cardiac activation wave.
  • Estimated propagation velocity from UCSDI (0.25 +/- 0.05 mm/ms) was comparable to ECG measurements.
  • Achieved a maximum AE signal-to-noise ratio of 18 dB with a detection threshold of 0.1 mA/cm(2).

Conclusions:

  • Demonstrates UCSDI as a potentially powerful technique for mapping cardiac current flow and biopotentials.
  • Highlights UCSDI's capability to provide detailed, high-resolution maps of cardiac electrical activity.