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Updated: Jun 23, 2026
Rat Model of the Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy (ALPPS) Procedure
Published on: August 14, 2017
Quantification of hepatic arterial and portal perfusion with dynamic computed tomography: comparison of maximum-slope
Masaya Miyazaki1, Yoshito Tsushima, Akiko Miyazaki
1Department of Diagnostic and Interventional Radiology, Gunma University Graduate School of Medicine, Maebashi, 371-8511, Japan. miyazaki8612@polka.ocn.ne.jp
Purpose:
The aim of this study was to compare the maximum-slope (MS) and dual-input one-compartment model (DOCM) methods in hepatic perfusion computed tomography (CT).
Materials And Methods:
A total of 37 patients with known or suspected liver disease underwent single-location dynamic CT after arterial or venous bolus injection of contrast material. Perfusion CT images were created by the MS (dividing the peak gradient of the time-attenuation curve by the peak vessel CT number) and DOCM-calculating from the equation dC ( L )(t)/dt = k ( a ) C ( a )(t - tau( a )) + k ( p ) C ( p )(t - tau( p )) - k ( v ) C ( L )(t)-methods. The perfusion parameters hepatic arterial perfusion (HAP), portal venous perfusion (PVP), and hepatic perfusion index (HPI) were determined.
Results:
The PVP of the tumor-free hepatic parenchyma determined by the MS method was lower than that obtained by the DOCM method (P < 0.001) with both injections. HAP determined by the MS method was lower than that obtained by the DOCM method with venous injection (P = 0.001), although there was no difference between the methods for HAP with arterial injection (P = 0.154). Most of the perfusion parameters showed linear correlations between the two analytical methods.
Conclusion:
Except for HAP with arterial injection, the perfusion parameters obtained with the MS method were lower than those obtained with the DOCM method.
