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1Department of Medicine, McGill University, Montreal, Quebec, Canada. michael.pollak@mcgill.ca
Cell Metabolism
|May 7, 2009
Abstract:
A recent report by Kalaany and Sabatini concerning mechanisms underlying the inhibitory effect of dietary restriction on the growth of certain tumors adds to the evidence that insulin and IGF-I are hormones with relevance to oncology.
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Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
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