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[Acute poisoning by scilliroside].

P Azoyan1, R Garnier, H Poitrineau

  • 1Centre Anti-Poisons de Paris, France.

Journal De Toxicologie Clinique Et Experimentale
|May 1, 1991
PubMed
Summary
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A man ingested a rodenticide containing scilliroside, leading to severe cardiac issues. He developed a complete atrio-ventricular block and digitalization abnormalities, highlighting the cardiac toxicity of this compound.

Area of Science:

  • Cardiology
  • Toxicology
  • Pharmacology

Background:

  • Rodenticides containing cardiac glycosides, such as scilliroside, pose a significant poisoning risk.
  • Cardiac glycosides exert their effects by inhibiting the Na+/K+-ATPase pump, leading to increased intracellular calcium.

Observation:

  • A 43-year-old male with no prior cardiac history intentionally ingested 12 mg of scilliroside via rodenticide tablets.
  • The patient experienced persistent vomiting for 48 hours post-ingestion.
  • Upon admission at the 20th hour, electrocardiogram (EKG) revealed a complete atrio-ventricular block.

Findings:

  • The complete atrio-ventricular block resolved by the 4th day after ingestion.
  • EKG findings consistent with digitalization, including repolarization abnormalities, persisted until the 12th day.

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Implications:

  • This case underscores the potent cardiotoxic effects of scilliroside, even in individuals without pre-existing cardiac conditions.
  • Delayed recognition and management of scilliroside poisoning can lead to prolonged cardiac dysfunction.
  • Further research into the specific mechanisms and management strategies for scilliroside-induced cardiotoxicity is warranted.