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Enhanced low voltage cell electropermeabilization by boron nitride nanotubes
V Raffa1, G Ciofani, A Cuschieri
1Scuola Superiore Sant'Anna, Piazza Martiri della Libertà 33, 56127 Pisa, Italy. s.raffa@crim.sssup.it
Nanotechnology
|May 7, 2009
Summary
Boron nitride nanotubes (BNNTs) enable cell electropermeabilization using low electric fields. This study proposes BNNTs act as nanotools for enhanced cellular manipulation via their dielectric response.
Area of Science:
- Biomaterials science
- Nanotechnology
- Cell biology
Background:
- Boron nitride nanotubes (BNNTs) are structural analogues of carbon nanotubes (CNTs).
- BNNTs possess unique properties making them of significant scientific interest.
- Emerging research explores biomedical applications for BNNTs.
Purpose of the Study:
- To investigate the potential of BNNTs as nanotools for cell electropermeabilization.
- To demonstrate BNNT-enabled cell electropermeabilization at low electric field strengths.
Main Methods:
- In vitro study utilizing BNNTs.
- Application of low electric fields (40-60 V cm(-1)) for cell electropermeabilization.
- Analysis of BNNT dielectric response to static electric fields.
Main Results:
- BNNTs effectively enabled cell electropermeabilization.
- The process required significantly low electric fields (40-60 V cm(-1)).
- A mechanism based on BNNT dielectric response was proposed.
Conclusions:
- BNNTs can serve as effective nanotools for cell electropermeabilization.
- Low electric fields are sufficient for BNNT-mediated cell manipulation.
- The dielectric properties of BNNTs are key to their function in electropermeabilization.
