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Mean platelet volume in patients with coronary artery ectasia
Ercan Varol1, Selahattin Akcay, Mehmet Ozaydin
1Department of Cardiology, Suleyman Demirel University, Isparta, Turkey. drercanvarol@yahoo.com
Insights
Mean platelet volume (MPV), a marker of platelet activation, is significantly elevated in patients with coronary artery ectasia (CAE). This finding suggests MPV may play a role in CAE, a variant of coronary atherosclerosis.
Area of Science:
- Cardiology
- Hematology
Background:
- Coronary artery ectasia (CAE) is a variation of coronary atherosclerosis.
- Mean platelet volume (MPV) indicates platelet activation and is elevated in acute coronary syndromes.
Purpose of the Study:
- To investigate Mean platelet volume (MPV) levels in patients diagnosed with coronary artery ectasia (CAE).
Main Methods:
- Retrospective analysis of 366 patients with CAE and 160 control patients.
- MPV values were recorded and compared between the two groups.
Main Results:
- Patients with CAE exhibited significantly higher MPV values compared to controls (9.2 +/- 1.1 fl vs. 8.8 +/- 1.2 fl, P < 0.001).
- Platelet count was significantly lower in the CAE group (233.7 +/- 70.7 x10(9)/l) versus controls (264.7 +/- 102.8 x10(9)/l, P < 0.0001).
Conclusions:
- Mean platelet volume (MPV) is significantly elevated in patients with coronary artery ectasia (CAE).
- Elevated MPV may be associated with coronary artery ectasia.
Abstract:
Coronary artery ectasia (CAE) is a variant of coronary atherosclerosis. Mean platelet volume (MPV), an indicator of platelet activation, has been shown to be elevated in patients with acute coronary syndromes and myocardial infarction in the setting of obstructive coronary artery disease. The aim of this study was to assess the MPV in patients with CAE. We retrospectively studied 366 consecutive patients with CAE (195 men/171 women; mean age 55.4 +/- 10.9 years) and 160 control patients (81 men/79 women; mean age 53.5 +/- 10.2 years). MPV values were recorded in all study and control patients. The MPV values of patients with CAE were found to be significantly higher than those of the controls (9.2 +/- 1.1 versus 8.8 +/- 1.2 fl, respectively; P < 0.001). The platelet count was detected to be significantly lower in patients with CAE group than in patients with control group (233.7 +/- 70.7 versus 264.7 +/- 102.8 (x10(9)/l), respectively; P < 0.0001). We have shown that MPV was significantly elevated in patients with CAE compared with controls.
