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Related Concept Videos

The Retinoblastoma Gene01:20

The Retinoblastoma Gene

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
The Retinoblastoma Gene01:20

The Retinoblastoma Gene

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
Canonical Wnt Signaling Pathway02:54

Canonical Wnt Signaling Pathway

The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which results in tumor...

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Related Experiment Video

Updated: Jun 23, 2026

Comparing Metastatic Clear Cell Renal Cell Carcinoma Model Established in Mouse Kidney and on Chicken Chorioallantoic Membrane
05:36

Comparing Metastatic Clear Cell Renal Cell Carcinoma Model Established in Mouse Kidney and on Chicken Chorioallantoic Membrane

Published on: February 8, 2020

Wilms' tumor.

Andrew M Davidoff1

  • 1Department of Surgery, St Jude Children's Research Hospital, University of Tennessee College of Medicine, Memphis, TN 38105-3678, USA. andrew.davidoff@stjude.org

Current Opinion in Pediatrics
|May 7, 2009
PubMed
Summary
This summary is machine-generated.

Pediatric Wilms tumor survival now exceeds 90%, a significant improvement driven by systematic clinical trial advancements. Current research aims to maintain this high survival rate while reducing treatment toxicity in children.

Related Experiment Videos

Last Updated: Jun 23, 2026

Comparing Metastatic Clear Cell Renal Cell Carcinoma Model Established in Mouse Kidney and on Chicken Chorioallantoic Membrane
05:36

Comparing Metastatic Clear Cell Renal Cell Carcinoma Model Established in Mouse Kidney and on Chicken Chorioallantoic Membrane

Published on: February 8, 2020

Area of Science:

  • Pediatric oncology
  • Nephrology
  • Clinical trials

Background:

  • Wilms tumor is a common pediatric kidney cancer, accounting for most childhood kidney tumors.
  • Historically, survival rates were low, but have dramatically improved.
  • This review examines the evolution of Wilms tumor treatment through clinical trials.

Purpose of the Study:

  • To review clinical trial outcomes that have improved Wilms tumor survival.
  • To explain how trial data informs current and future Wilms tumor management strategies.
  • To highlight the development of risk-stratified therapies for pediatric kidney cancer.

Main Methods:

  • Review of historical and current clinical trial data for Wilms tumor.
  • Analysis of prognostic factors influencing patient outcomes.
  • Examination of risk stratification systems in pediatric oncology.

Main Results:

  • Survival for Wilms tumor patients has increased from less than 30% to over 90%.
  • Prognostic factors include tumor stage, histology, age, size, and genetic markers (1p/16q loss).
  • A new risk stratification system guides therapy assignment for pediatric kidney cancer patients.

Conclusions:

  • Systematic evolution of therapeutic approaches has led to excellent Wilms tumor survival rates.
  • Ongoing clinical trials aim to preserve high survival while minimizing treatment toxicity.
  • Further refinement of Wilms tumor management focuses on personalized, risk-adapted therapies.