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Simultaneous imaging and optode calibration with diffuse optical tomography.

D Boas, T Gaudette, S Arridge

|May 7, 2009

Summary

This summary is machine-generated.

Accurate diffuse optical tomography requires calibrating emitter and detector parameters. This study integrates calibration into the inverse problem, successfully reconstructing quantitative images from simulated data.

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Area of Science:

Biomedical optics
Image reconstruction
Optical tomography

Background:

Diffuse optical tomography (DOT) aims for quantitative imaging of optical properties in scattering media.
Experimental systematic errors, particularly emitter/detector calibration, hinder DOT accuracy.
Fluctuations in calibration parameters lead to significant image artifacts.

Purpose of the Study:

To develop and validate a method for incorporating emitter strength and detector efficiency/gain calibration into the DOT inverse problem.
To improve the quantitative accuracy of DOT imaging by addressing systematic calibration errors.

Main Methods:

A linear reconstruction model was employed for image reconstruction.
Simulated continuous-wave (CW) data was used to test the calibration technique.
The calibration parameters were included as part of the inverse problem during reconstruction.

Main Results:

The proposed technique successfully integrated calibration into the inverse problem.
Quantitative images with improved accuracy were reconstructed from simulated CW data.
The method demonstrated the feasibility of simultaneous calibration and image reconstruction.

Conclusions:

Integrating emitter and detector calibration into the inverse problem is a viable strategy for enhancing DOT accuracy.
This approach mitigates image artifacts caused by calibration fluctuations.
The technique is applicable to both continuous-wave and frequency/time-domain DOT data.