Related Experiment Video

Updated: Jun 23, 2026

Heterotypic Three-dimensional In Vitro Modeling of Stromal-Epithelial Interactions During Ovarian Cancer Initiation and Progression
12:42

Heterotypic Three-dimensional In Vitro Modeling of Stromal-Epithelial Interactions During Ovarian Cancer Initiation and Progression

Published on: August 28, 2012

Polymorphisms in TCEAL7 and risk of epithelial ovarian cancer

Abraham Peedicayil1, Robert A Vierkant, Vijayalakshmi Shridhar

  • 1Department of Health Sciences Research, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA.

Gynecologic Oncology
|May 8, 2009
PubMed
Abstract

Insights

Inherited variations in TCEAL7 (transcription elongation factor A (SII)-like 7) may influence the development of invasive serous ovarian cancer. Further research is recommended to confirm these findings.

Area of Science:

  • Genetics
  • Oncology
  • Molecular Biology

Background:

  • Transcription elongation factor A (SII)-like 7 (TCEAL7) is epigenetically downregulated in most epithelial ovarian cancers.
  • Previous research suggests TCEAL7's role in ovarian cancer etiology.

Purpose of the Study:

  • To investigate the hypothesis that inherited genetic alterations in TCEAL7 contribute to ovarian cancer development.
  • To analyze the association between TCEAL7 polymorphisms and ovarian cancer risk.

Main Methods:

  • A case-control study involving 930 ovarian cancer cases and 1037 controls.
  • Genotyping of six single nucleotide polymorphisms (SNPs) and haplotype analysis.
  • Logistic regression and principal component analysis to assess risk associations.

Main Results:

  • No overall significant association between TCEAL7 SNPs or haplotypes and ovarian cancer risk.
  • A significant association with reduced risk was observed for minor alleles of three correlated SNPs in invasive serous ovarian cancer cases (p<0.05).
  • Gene-level variation and the predominant haplotype showed a trend towards reduced risk in cases (p=0.05).

Conclusions:

  • TCEAL7 polymorphisms may be implicated in the pathogenesis of invasive serous ovarian cancer.
  • Further molecular and replication studies are necessary to validate these preliminary findings.

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