Related Experiment Video
Updated: Jun 23, 2026

High-throughput Synthesis of Carbohydrates and Functionalization of Polyanhydride Nanoparticles
Published on: July 6, 2012
Multivalent mannose-displaying nanoparticles constructed from poly{styrene-co-[(maleic anhydride)-alt-styrene]}
Rongmin Su1, Lei Li, Xiaoping Chen
1Department of Chemistry, College of Chemistry and Chemical Engineering, and The Key Laboratory for Chemical Biology of Fujian Province, Xiamen University, 361005, P. R. China.
Abstract:
Micellar mannose nanoparticles were constructed from poly{styrene-co-[(maleic anhydride)-alt-styrene]} with fluorophores or quenchers doped into the hydrophobic inner cores, allowing the direct monitoring of multivalent lectin-glycan interactions. The mannose-displaying nanoparticles bind Con A and sperm surface lectins with high affinity, suggesting their broad utility for modulating protein-carbohydrate interaction mediated cell surface biology.

