Related Experiment Video
Updated: Jun 23, 2026
Transoral Endoscopic Thyroidectomy Vestibular Approach for Thyroid Lobectomy
Published on: May 12, 2023
The effectiveness of FloSeal matrix hemostatic agent in thyroid surgery: a prospective, randomized, control study
Mario Testini1, Rinaldo Marzaioli, Germana Lissidini
1Section of General and Thoracic Surgery, Department of Applications in Surgery of Innovative Technologies, University Medical School of Bari, Policlinico, Piazza G. Cesare 11, 70124, Bari, Italy. mario.testini@chirgen2.uniba.it
Background:
The objective of this study was to compare the effectiveness of FloSeal matrix hemostatic agent with hemostatic surgical procedures and Tabotamp in thyroid surgery.
Methods:
One hundred fifty-five consecutive total thyroidectomy patients were recruited at our institution between January 2005 and December 2007. Exclusion criteria were applied. Patients were randomized to one of three hemostatic approaches: 49 received surgical procedures only, and 52 received oxidized regenerated cellulose patch (Tabotamp Fibrillar 2.5 x 5 cm) and 54 FloSeal (5,000 U/5 mL). The same surgeon performed all operations.
Results:
Mean operating time was reduced in the FloSeal group (105 min) vs. surgical (133 min, p = 0.02) and vs. Tabotamp (122 min, p = 0.0003). Also, wound drain removal occurred earlier with FloSeal (p = 0.006 vs. surgical; p = 0.008 vs. Tabotamp) resulting in shorter postoperative hospital stay in the FloSeal group (p = 0.02 vs. surgical; p = 0.002 vs. Tabotamp).
Conclusions:
FloSeal matrix is an effective additional agent to conventional haemostatic procedures in thyroid surgery.