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Updated: Jun 23, 2026

18F-Labeling of Radiotracers Functionalized with a Silicon Fluoride Acceptor (SiFA) for Positron Emission Tomography
Published on: January 11, 2020
[18F]SiFA-isothiocyanate: a new highly effective radioactive labeling agent for lysine-containing proteins
Pedro Rosa-Neto1, Björn Wängler, Ljuba Iovkova
1Montreal Neurological Institute, McGill University, Douglas Research Institute, Montreal, H3A 2B4, Canada.
Abstract:
A highly efficient (18)F-labeling synthon for universal protein labeling is reported. Diverse (18)F-labeled proteins of 66-144 kDa were prepared with [(18)F]SiFA-isothiocyanate synthesized by an isotopic (19)F for (18)F exchange at the silicon atom. Overall preparative radiochemical yields were 20-40 % after 40-50 min. No bone uptake of (18)F radioactivity was detected until 90 min post-injection of (18)F-SiFA-RSA; this demonstrates the metabolic stability of the [(18)F]SiFA moiety.
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