Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bipolar Disorder01:30

Bipolar Disorder

Bipolar disorder is a chronic mental health condition marked by significant mood fluctuations, including episodes of mania and depression. Elevated energy levels, heightened mood or irritability, impulsive behavior, reduced sleep needs, rapid speech, racing thoughts, inflated self-esteem, and distractibility characterize mania. Individuals with bipolar disorder often alternate between depressive and manic states, with periods of emotional stability lasting an average of six months to a year.
Electrophysiology of Normal Cardiac Rhythm01:19

Electrophysiology of Normal Cardiac Rhythm

The normal cardiac rhythm is a synchronized electrical activity that facilitates the regular and coordinated contraction of the heart muscle. This process is essential for efficient blood circulation throughout the body. The fundamental elements involved in establishing and maintaining this rhythm include the unique electrical properties of cardiac muscle cells, the sinoatrial (SA) node's pacemaker function, the specialized conducting system, and the ionic mechanisms underlying each phase of...
Structure and Function of Platelets01:18

Structure and Function of Platelets

The cell fragments known as platelets are disc-shaped, with an average diameter of about 3 μm and a thickness of roughly 1 μm. They play a crucial role in the body's vascular clotting system, which also involves plasma proteins, blood cells, and blood vessel tissues.
Platelets are continually replenished, circulating in the bloodstream for 9-12 days before being removed by phagocytes, primarily in the spleen. A microliter of circulating blood contains between 150,000 and 450,000 platelets, with...
Formation of the Platelet Plug01:22

Formation of the Platelet Plug

The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors01:20

Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors

Antiplatelet drugs emerge as frontline defenders against the insidious threat of thromboembolic diseases, where abnormal clots obstruct vital blood vessels. These drugs stand as bulwarks, inhibiting platelet aggregation and clot formation, thereby mitigating the risk of life-threatening conditions like myocardial infarction, coronary artery disease, and thrombotic strokes.
Prostaglandin synthesis inhibitors, exemplified by the widely known aspirin, wield their power by irreversibly acetylating...
Dysrhythmias VI: Management of Dysrhythmias01:25

Dysrhythmias VI: Management of Dysrhythmias

Dysrhythmia management involves a multifaceted approach, incorporating pharmacological treatments, medical procedures, surgical interventions, lifestyle modifications, and patient education.Pharmacological ManagementAntiarrhythmic Drugs:Class I (Sodium Channel Blockers): This class includes quinidine and procainamide, which reduce the speed of impulse conduction in the heart, stabilize the cardiac membrane, and control arrhythmias. Quinidine and procainamide are Class IA agents that prolong the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Prevention of depression in patients with atrial fibrillation using an online personalized intervention: The HOPE-AF feasibility study.

European journal of cardiovascular nursing·2026
Same author

Kidney disease increases the risk of cardiovascular events in patients with device-detected atrial fibrillation: NOAH-AFNET 6.

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology·2026
Same author

Inflammation and day-to-day occurrence of atrial fibrillation.

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology·2026
Same author

[Consumer wearables, cardiology and clinical practice].

Ugeskrift for laeger·2026
Same author

The cost-effectiveness of implantable loop recorder detection of atrial fibrillation to prevent stroke in persons at high risk: An economic evaluation alongside a multicentre randomised controlled trial in Denmark (The LOOP Study).

The European journal of health economics : HEPAC : health economics in prevention and care·2026
Same author

Effects of Atrial Fibrillation Screening According to Echocardiographic Measures of Cardiac Structure and Function: A Post Hoc Analysis of the LOOP Randomized Clinical Trial.

Journal of the American Heart Association·2025
Same journal

A Case of Permanent Pacemaker Implantation via the Epicardial Approach Using the 3830 Lead in an 11-Day-Old Neonate (With Follow-Up of the Above Case).

Pacing and clinical electrophysiology : PACE·2026
Same journal

Cryoballoon Versus Radiofrequency Ablation for Persistent Atrial Fibrillation: Meta-Analysis of Randomized Trials.

Pacing and clinical electrophysiology : PACE·2026
Same journal

Tilt Test Duration in Suspected Vasovagal Syncope: Temporal Patterns and Diagnostic Yield in Patients From Central China.

Pacing and clinical electrophysiology : PACE·2026
Same journal

Combined Leadless Pacing and Subcutaneous ICD Therapy in Long QT Syndromes.

Pacing and clinical electrophysiology : PACE·2026
Same journal

Association of Anesthesia Modality With Procedural Parameters and Clinical Outcomes in PVI for Atrial Fibrillation.

Pacing and clinical electrophysiology : PACE·2026
Same journal

Zero-Fluoroscopy Cryoballoon Ablation for Paroxysmal Atrial Fibrillation in a Patient With Dextrocardia: A Case Report.

Pacing and clinical electrophysiology : PACE·2026
See all related articles

Related Experiment Video

Updated: Jun 23, 2026

Dynamic Multiparameter Platelet Function Assessment Using a Capacitive Biosensor
06:32

Dynamic Multiparameter Platelet Function Assessment Using a Capacitive Biosensor

Published on: May 2, 2025

Does bipolar pacemaker current activate blood platelets?

Grunde Gjesdal1, Annebirthe Bo Hansen, Axel Brandes

  • 1Department of Cardiology, Odense University Hospital, Odense, Denmark. Grunde.Gjesdal@skane.se

Pacing and Clinical Electrophysiology : PACE
|May 9, 2009
PubMed
Summary
This summary is machine-generated.

Bipolar pacemaker current can activate blood platelets, increasing their reactivity to adenosine diphosphate (ADP). This study found that electrical stimulation of platelets alters their function, warranting further clinical investigation.

More Related Videos

Comprehensive Analysis of Procoagulant Platelets Exhibiting Features of Necrosis, Apoptosis and Platelet Activation
04:37

Comprehensive Analysis of Procoagulant Platelets Exhibiting Features of Necrosis, Apoptosis and Platelet Activation

Published on: May 23, 2025

Procoagulant Platelet Characterization by Measuring Phosphatidylserine Exposure and Microvesicle Release from Human Purified Platelets
05:49

Procoagulant Platelet Characterization by Measuring Phosphatidylserine Exposure and Microvesicle Release from Human Purified Platelets

Published on: November 29, 2024

Related Experiment Videos

Last Updated: Jun 23, 2026

Dynamic Multiparameter Platelet Function Assessment Using a Capacitive Biosensor
06:32

Dynamic Multiparameter Platelet Function Assessment Using a Capacitive Biosensor

Published on: May 2, 2025

Comprehensive Analysis of Procoagulant Platelets Exhibiting Features of Necrosis, Apoptosis and Platelet Activation
04:37

Comprehensive Analysis of Procoagulant Platelets Exhibiting Features of Necrosis, Apoptosis and Platelet Activation

Published on: May 23, 2025

Procoagulant Platelet Characterization by Measuring Phosphatidylserine Exposure and Microvesicle Release from Human Purified Platelets
05:49

Procoagulant Platelet Characterization by Measuring Phosphatidylserine Exposure and Microvesicle Release from Human Purified Platelets

Published on: November 29, 2024

Area of Science:

  • Biomedical Engineering
  • Hematology
  • Cardiology

Background:

  • Platelets and muscle cells share contractile proteins and respond to calcium influx.
  • Electrical stimulation of muscle cells causes contraction.
  • Pacemaker leads deliver electrical currents that may affect nearby blood components.

Purpose of the Study:

  • To determine if bipolar pacemaker current can activate blood platelets.
  • To test the hypothesis that electrical stimulation does not affect platelet reactivity to adenosine diphosphate (ADP).

Main Methods:

  • Prepared platelet-rich plasma from healthy donors.
  • Assessed platelet reactivity to ADP using an aggregometer in a case-control design.
  • Exposed one sample to bipolar pacemaker current and compared it to a control.

Main Results:

  • Increased platelet reactivity to ADP was observed in 18 out of 46 stimulated samples.
  • No significant change in reactivity was seen in 26 samples.
  • The null hypothesis was rejected, indicating a statistically significant effect (P = 0.0004).

Conclusions:

  • In vitro exposure to pacemaker current increases platelet reactivity to ADP.
  • The clinical significance of this observed platelet activation requires further research.