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Related Concept Videos

Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their access...
Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

Overview
Tissue Transplantation01:24

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...

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Related Experiment Video

Updated: Jun 23, 2026

Isolation of Perivascular Multipotent Precursor Cell Populations from Human Cardiac Tissue
08:15

Isolation of Perivascular Multipotent Precursor Cell Populations from Human Cardiac Tissue

Published on: October 8, 2016

Mesenchymal stem cells can affect solid organ allograft survival.

Felix C Popp1, Elke Eggenhofer, Philipp Renner

  • 1Department of Surgery, University Medical Center Regensburg, Regensburg, Germany. felix.popp@klinik.uni-regensburg.de

Transplantation
|May 9, 2009
PubMed
Summary

Mesenchymal stem cells (MSCs) from bone marrow can modulate immune responses. Further research into MSC mechanisms is crucial for developing new transplant antirejection therapies.

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Isolation of Perivascular Multipotent Precursor Cell Populations from Human Cardiac Tissue
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A Novel Microsurgical Model for Heterotopic, En Bloc Chest Wall, Thymus, and Heart Transplantation in Mice
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Assessment of the Immunomodulatory Properties of Human Mesenchymal Stem Cells (MSCs)
06:20

Assessment of the Immunomodulatory Properties of Human Mesenchymal Stem Cells (MSCs)

Published on: December 24, 2015

Area of Science:

  • Immunology
  • Regenerative Medicine
  • Transplantation Science

Background:

  • Mesenchymal stem cells (MSCs) show immunomodulatory potential in vitro and in vivo.
  • Large-scale expansion of MSCs is feasible for clinical applications.
  • Understanding MSCs' mechanisms is key for developing anti-rejection treatments.

Purpose of the Study:

  • To elucidate the immunomodulatory mechanisms of mesenchymal stem cells (MSCs).
  • To review the in vitro effects of MSCs on immune effector cells.
  • To summarize the current understanding of MSCs' in vivo properties.

Main Methods:

  • Review of recent findings on MSCs' in vitro immunomodulatory effects.
  • Summary of available data on MSCs' in vivo properties.

Main Results:

  • MSCs demonstrate significant immunomodulatory capabilities.
  • In vitro studies report various effects of MSCs on immune cells.
  • In vivo data on MSC properties are still limited but emerging.

Conclusions:

  • Mesenchymal stem cells (MSCs) hold promise for modulating immune responses in transplantation.
  • Further investigation into MSCs' in vivo functions is necessary.
  • Elucidating MSC mechanisms will advance the development of novel antirejection strategies.